The M5 (m5) receptor subtype: Fact or fiction?
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Keywords
autoradiography
muscarinic receptors
m5 receptor
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The nomenclature for muscarinic receptor subtypes has designated the big “M” terminology for the pharmacologically-defined receptors and the small “m” terminology for the molecularly-defined receptors. It is now clear that the ml sequence corresponds to the M1 receptor, the m2 to the M2, etc. Since the receptor subtype-selectivity of the pharmacological labeling strategies described here have been validated using the individual molecular receptors expressed in transfected cells, we have utilized the small “m” terminology to refer to the respective receptors labeled by each of the subtype-selective conditions.
Copyright © 1997 Published by Elsevier Inc.