Effects of cannabinoids on energy metabolism
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Antiinflammatory and antioxidant and immunomodulatory effects of phytocannabinoid β-caryophyllene: A mechanistic review
2023, Medicinal Usage of Cannabis and CannabinoidsPotential anti-epileptic phytoconstituents: An updated review
2021, Journal of EthnopharmacologyCitation Excerpt :This indicated its potential to reduce seizure by reducing TBARS and increasing NPSH levels in KA model. It has not shown any motor impairments in experimental animals in open-field, rotarod and forced swim test respectively (Guzmán and Sánchez, 1999; Schlicker and Kathmann, 2001; Clayton et al., 2002; Gertsch et al., 2008; Al Mansouri et al., 2014; Fidyt et al., 2016; Oliveira et al., 2016). Baicalin is a flavonoid glycoside obtained from Scutellaria baicalensis Georgi.
Cannabinoid Receptors and Their Signaling Mechanisms
2017, The Endocannabinoid System: Genetics, Biochemistry, Brain Disorders, and TherapyFunctional selectivity at G-protein coupled receptors: Advancing cannabinoid receptors as drug targets
2017, Biochemical PharmacologyCitation Excerpt :Other receptors, including GPR55 and GPR119 and members of the transient receptor potential (TRP) family, also bind select endogenous and pharmacologically active synthetic cannabinergic ligands [29,30]. Cannabinoid receptors have been implicated in the regulation of a variety of central and peripheral physiological processes including neurogenesis [31], neuromodulation [32], energy balance and metabolism [33,34], immune-system activity [35], thermoregulation [36], and reproduction [37]. It is thus unremarkable that aberrant CB1R- or CB2R-dependent signaling is implicated in a number of disease states that represent major unsolved medical problems for which CBRs are considered key drug targets.
Morphine produces immunosuppressive effects in nonhuman primates at the proteomic and cellular levels
2012, Molecular and Cellular ProteomicsCitation Excerpt :A number of studies have identified links between immunosuppression and changes in energy metabolism, which fuels defense functions (76, 77). In fact other drugs such as cannabinoids are known to reduce energy metabolism and possess immunosuppressive properties (78). The impact by morphine on energy metabolism may represent a centralized functional hub in the lymph node that contributes immunosuppression.
Allosteric modulator ORG27569 induces CB1 cannabinoid receptor high affinity agonist binding state, receptor internalization, and Gi protein-independent ERK1/2 kinase activation
2012, Journal of Biological ChemistryCitation Excerpt :Another possible mechanism may involve a factor associated with neutral sphingomyelinase. It has been shown that CB1-mediated release of ceramide through sphingomyelin hydrolysis activates ERK signaling, and this activation may be Gi/o-independent (72–74). Because allosteric modulators bind a site remote from the orthosteric ligand binding site and regulate its binding affinity, their selectivity can be of enormous advantage.