Supraspinal and spinal effects of [Phe1Ψ(CH2-NH)Gly2]-nociceptin(1–13)-NH2 on nociception in the rat
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Cited by (22)
Nociceptive behavior and central neuropeptidergic dysregulations in male and female mice of a Fabry disease animal model
2021, Brain Research BulletinCitation Excerpt :Moreover, the dynorphin - KOP receptor system contributes to the negative affective component of pain (Cahill et al., 2014; Malan et al., 2000; Palmisano et al., 2019). A role for the nociceptin/orphanin FQ - NOP receptor system in pain modulation has been ascertained (Candeletti et al., 1999; Kiguchi et al., 2016; Meunier et al., 1995; Palmisano et al., 2017). The ability of NOP antagonist JTC-801 to reverse anxiety- and pain-like behaviors has been recently reported (Zhang et al., 2015), thus suggesting a common target for comorbidity of stress disorder and pain.
Pharmacological Modulation of Endogenous Opioid Activity to Attenuate Neuropathic Pain in Rats
2019, Journal of PainCitation Excerpt :Importantly, a number of studies have indicated the absence of significant supraspinal effects of i.t. injectate, even 60 minutes following i.t. injection.1,29,38 The i.t. doses of MPP (10 nmol), YM298198 (25 nmol), fadrozole (2.5 nmol), and naloxone (25 nmol) were based on previous studies,8,11,18,35,44,46,47,62 in order to maintain parallelism of i.t. treatments used in the current report and its 2 antecedent studies.46,47 Mechanical allodynia was quantified by measuring paw withdrawal thresholds of both ipsilateral and contralateral hind paws in response to the application of von Frey hair, as described by Chaplan et al.10 In brief, rats were placed on a wire mesh surface covered by an inverted plastic cage and were allowed to habituate for 15 minutes.
Acute and subchronic antinociceptive effects of nociceptin/orphanin FQ receptor agonists infused by intrathecal route in rats
2015, European Journal of PharmacologyCitation Excerpt :This result is not completely unexpected. In fact, the NOP partial agonist [F/G]N/OFQ(1–13)–NH2 that shares with UFP-113 the chemical modification at the Phe1-Gly2 peptide bond that reduces efficacy (Calo׳ et al., 2000) displayed full agonist activity when given spinally in the rat tail flick test (Candeletti et al., 2000, Wang et al., 1999). Doses higher than 0.3 nmol for UFP-112 and 1 nmol for UFP-113 induced disruption of motor coordination.
Nociceptin produces antinociception after spinal administration in amphibians
2009, Pharmacology Biochemistry and Behavior