Conversion of cortisol to cortisol acetate, cortisone acetate and cortisone by the developing primate brain
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Cited by (18)
11β-Hydroxysteroid dehydrogenases and the brain: From zero to hero, a decade of progress
2011, Frontiers in NeuroendocrinologyCitation Excerpt :It was originally described in neuronal and glial cell lines in the 1960s. Using at that time cutting-edge histochemical and biochemical techniques, 11-keto oxidation of steroids was found in mouse, rat, dog and primate whole brain extracts, as well as fetal brain and the C6 glioma cell line [86,87,175,209,252]. Thereafter, inter-conversion of radiolabelled cortisol and cortisone in vivo and in vitro confirmed 11β-HSD activity in mouse brain, at lower levels than found in liver, kidney and placenta [33].
Chapter 3.3 The role of 11β-hydroxysteroid dehydrogenases in the regulation of corticosteroid activity in the brain
2005, Techniques in the Behavioral and Neural SciencesCitation Excerpt :These data also strongly suggest that 11β-HSD1 is responsible for this brain activity, since purified 11β-HSD2 is potentiated only by NAD (Brown et al., 1993), albeit various tissues can interconvert the dinucleotides in vivo. 11β-HSD activity has been reported in rat, mouse, dog and primate brain (Grosser, 1966; Grosser and Axelrod, 1968; Miyabo et al., 1973). Biochemical, immunological and molecular studies suggest that it is 11β-HSD1 that is responsible for widespread CNS activity.
11β-Hydroxysteroid dehydrogenase in the brain: A novel regulator of glucocorticoid action?
1997, Frontiers in NeuroendocrinologyDifferential inhibition of 11β-hydroxysteroid dehydrogenase by carbenoxolone in rat brain regions and peripheral tissues
1993, Journal of Steroid Biochemistry and Molecular Biology11β-Hydroxysteroid Dehydrogenase
1993, Vitamins and HormonesThe responses of the developing endocrine system to hormones and drugs
1980, Pharmacology and Therapeutics
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Present address: Department of Psychiatry, University of Utah College of Medicine, Salt Lake City, Utah 84112.