Elsevier

Steroids

Volume 11, Issue 6, June 1968, Pages 827-836
Steroids

Conversion of cortisol to cortisol acetate, cortisone acetate and cortisone by the developing primate brain

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Abstract

Cortisol is converted to cortisone by minces of cerebellum, thalamus-hypothalamus, brain stem (medulla), and cortex obtained from the brains of second trimester, third trimester, newborn, and adult baboons. The 11β-hydroxysteroid dehydrogenase activity appears to be greatest in the cerebellum of the third trimester brain.

Significant quantities of cortisol acetate and cortisone acetate are formed in the fetal and newborn brain; however, there is apparently a decrease in isolated acetylated products from the adult brain under the conditions of these experiments.

References (16)

  • GrosserB.I. et al.

    Steroids

    (1967)
  • GrosserB.I. et al.

    Steroids

    (1966)
  • SholitonL.J. et al.

    Metabolism

    (1965)
  • Eik-NesK.B. et al.

    Biochim. Biophys. Acta

    (1965)
  • MargrafH.W. et al.

    Steroids

    (1963)
  • GrosserB.I. et al.
  • GrosserB.I. et al.
  • PetersonN.A. et al.

    J. Neurochem.

    (1965)
There are more references available in the full text version of this article.

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Present address: Department of Psychiatry, University of Utah College of Medicine, Salt Lake City, Utah 84112.

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