Chapter 26. The Cannabinoids: Therapeutic Potentials

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This chapter describes the therapeutic potentials of the cannabinoids. In regard to marijuana or its active component, Δ-THC, the potential medical applications have been presented. Δ-THC inhibits the in vitro biosynthesis of prostaglandin E2 (PGE2) from arachidonic acid and the biosynthesis of PGE1 from 8,11,14-eicosatrienic acid. The inhibition of PGE2 biosynthesis has been postulated as a mechanism of action for such nonsteroidal anti-inflammatory agents as aspirin and indomethacin. At a dose of 2 mg in rats, Δ-THC suppressed the cyclic surge of luteinizing hormone secretion and also suppressed ovulation. The mating and fertility indices were similar for control and all treatment groups in a study of the effect of Δ-THC on reproduction in rats. At doses of 2 and 3 mg/kg, Δ-THC caused deterioration in the sexual performance of male rats. Pretreatment of mice for six successive days at 20 mg/kg of Δ-THC, caused a decrease in the duration of sleeping time after dosing with zoxazolamine and hexobarbital.

References (50)

  • S. Burstein et al.

    Prostaglandins

    (1972)
  • S. Burstein et al.

    Biochem. Pharmacol.

    (1973)
  • D.S. Kosersky et al.

    Eur. J. Pharmacol.

    (1973)
  • R. Karler et al.

    Life Sci.

    (1973)
  • J.A. Wada et al.

    Experimental Neurology

    (1973)
  • I. Cavero et al.

    Eur. J. Pharmacol.

    (1972)
  • I. Cavero et al.

    Eur. J. Pharmacol.

    (1973)
  • I. Cavero et al.

    Eur. J. Pharmacol.

    (1973)
  • M.B. Wallach et al.

    Eur. J. Pharmacol.

    (1973)
  • J.E. Moreton et al.

    Neuropharmacology

    (1973)
  • H.C. Sabelli et al.

    Life Sci.

    (1974)
  • The term “cannabinoids” has been defined as the group of C21 compounds typical of and present in Cannabis sativa, their...
  • L. Hollister

    Psychopharmacologia

    (1972)
  • J.R. Vane

    Nature New Biol.

    (1971)
  • R.D. Sofia et al.

    Res. Commun. Chem. Pathol. Pharmacol.

    (1973)
  • R.D. Sofia et al.

    J. Pharmacol. Exp. Therapeutics

    (1973)
  • I. Nir et al.

    Nature

    (1973)
  • M.L. Keplinger et al.

    Toxicol. Appl. Pharmacol.

    (1973)
  • A. Merari et al.

    Psychopharmacologia

    (1973)
  • J.A. Wada et al.

    Epilepsia

    (1973)
  • R. Karter

    Fed. Proc.

    (1973)
  • H.F. Hardman et al.

    Pharmacol. Rev.

    (1971)
  • R.B. Williams et al.

    Psychopharmacologia

    (1973)
  • M.K. Birmingham

    Br. J. Pharmacol.

    (1973)
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