Structural reorganization of hippocampal networks caused by seizure activity

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This chapter focuses on the last category of brain abnormalities associated with epilepsy-brain abnormalities caused by the seizure activity itself. From a historical perspective, the acceptance of the idea of seizure-induced effects on the brain is relatively recent. Whereas the connection between preexisting lesions and epilepsy can be found in some of the earliest texts concerning medicine, major debates as to whether seizure activity itself could actually cause neuronal injury still persists. The ictal activity leading to the expression of a specific gene product has been demonstrated recently. Recent advances in methods for analyzing the nervous system from the genetic to the network level, however, have led to an enormous literature concerning seizure-induced effects on the brain.

References (146)

  • M. Gastaldi et al.

    Increase in mRNAs encoding neonatal II and III sodium channel alpha-isoforms during kainate-induced seizures in adult rat hippocampus

    Brain Res. Mol. Brain Res.

    (1997)
  • E. Gould et al.

    Lesion-induced proliferation of neuronal progenitors in the dentate gyrus of the adult rat

    Neuroscience

    (1997)
  • W. Gray et al.

    Kainic acid increases the proliferation of granule cell progenitors in the dentate gyros of the adult rat

    Brain Res.

    (1998)
  • Z. He et al.

    Neuropilin is a receptor for the axonal chemorepellent Semaphorin III

    Cell

    (1997)
  • C. Houser

    Granule cell disperson in the dentate gyrus of humans with temporal lobe epilepsy

    Brain Res.

    (1990)
  • Y. Ichimiya et al.

    Loss of calbindin-D28k immunoreactive neurones from the cortex in Alzheimer-type dementia

    Brain Res.

    (1988)
  • F. Keller et al.

    A membrane glycoprotein associated with the limbic system mediates the formation of the septa-hippocampal pathway in vitro

    Neuron

    (1989)
  • G. Klapstein et al.

    Calbindin-D28k fails to protect hippocampal neurons against ischemia in spite of its cytoplasmic calcium buffering properties: evidence from calbindin-D28k knockout mice

    Neuroscience

    (1998)
  • A. Kolodkin et al.

    Neuropilin is a semaphorin III receptor

    Cell

    (1997)
  • W. Liu et al.

    Status epilepticus induces p53 sequence-specific DNA binding in mature rat brain

    Mol. Brain Res.

    (1999)
  • F. Livesey et al.

    Netrin and netrin receptor expression in the embryonic mammalian nervous system suggests roles in retinal, striatal, nigral, and cerebellar development

    Mol. Cell. Neurosci.

    (1997)
  • B. Longo et al.

    Blockade of pilocarpine- or kainate-induced mossy fiber sprouting by cycloheximide does not prevent subsequent epileptogenesis in rats

    Neurosci. Lett.

    (1997)
  • B. Longo et al.

    Supragranular mossy fiber sprouting is not necessary for spontaneous seizures in the intrahippocampal kainate model of epilepsy in the rat

    Epilepsy Res.

    (1998)
  • D. Lowenstein et al.

    Dentate granule cell layer collagen explant cultures: Spontaneous axonal growth and induction by brain-derived neurotrophic factor or basic fibroblast growth factor

    Neuroscience

    (1996)
  • D. Lowenstein et al.

    Up-regulation of calbindin-D28K mRNA in the rat hippocampas following focal stimulation of the perforant path

    Neuron

    (1991)
  • D. Lowenstein et al.

    Increased expression of mRNA encoding calbindin-D28K, the glucose-regulated proteins, or the 72 kDA heat-shock protein in three models of acute CNS injury

    Brain Res. Mol. Brain Res.

    (1994)
  • M. Mattson et al.

    Evidence for calcium-reducing and excitoprotective roles for the calcium binding protein calbindin-D28K in cultured hippocampal neurons

    Neuron

    (1991)
  • J. Nadler et al.

    Loss and reacquisition of hippocampal synapses after selective destruction of CA3-CA4 afferents with kainic acid

    Brain Res.

    (1980)
  • J. Olney et al.

    Acute dendrotoxic changes in the hippocampus of kainate treated rats

    Brain Res.

    (1979)
  • J. Parent et al.

    Increased dentate granule cell neurogenesis following amygdala kindling in the adult rat

    Neurosci. Lett.

    (1998)
  • M. Patel et al.

    Selective enhancement of axonal branching of cultured dentate gyrus neurons by neurotrophic factors

    Neuroscience

    (1995)
  • A. Abosch et al.

    Netrin responsiveness of developing hippocampus

    Epilepsia

    (1998)
  • J. Altman et al.

    Autoradiographic and histological studies of postnatal neurogenesis. 1. A longitudinal investigation of the kinetics, migration and transformation of cells incorporating tritiated thymidine in neonatal rats, with special reference to postnatal neurogenesis in some brain regions

    J. Comp. Neurol.

    (1966)
  • J. Altman et al.

    Postnatal neurogenesis in the guinea-pig

    Nature

    (1967)
  • J. Angevine

    Time of neuron origin in the hippocampal region: an autoradiographic study in the mouse

    Exp. Neurol.

    (1965)
  • R. Babb et al.

    Synaptic reorganization by mossy fibers in human epileptic fascia dentata

    Neuroscience

    (1991)
  • T. Babb et al.

    Glutamate decarboxylase-immunoreactive neurons are preserved in human epileptic hippocmpus

    J. Neurosci.

    (1989)
  • M. Baulac et al.

    Hippocampal developmental changes in patients with partial epilepsy: Magnetic resonance imaging and clinical aspects

    Ann. Neural.

    (1998)
  • J. Bengzon et al.

    Apoptosis and proliferation of dentate gyrus neurons after single and intermittent limbic seizures

  • C. Boucher et al.

    De l'epilepsie consideree dans ses rapports avec l'alientation mentale

    Arch. Gen. Med.

    (1825)
  • C. Bruton

    The Neuropathology of Temporal Lobe Epilepsy

    (1988)
  • E. Buhl et al.

    Zinc-induced collapse of augmented inhibition by GABA in a temporal lobe epilepsy model

    Science

    (1996)
  • H. Cameron et al.

    Regulation of adult neurogenesis by excitatory input and NMDA receptor activation in the dentate gyrus

    J. Neurosci.

    (1995)
  • F. Cendes et al.

    Temporal lobe epilepsy caused by domoic acid intoxication: evidence for glutamate receptor-mediated excitotoxicity in humans

    Ann. Neural.

    (1995)
  • A. Chédotal et al.

    Semaphorins III and IV repel hippocampal axons via two distinct receptors

    Development

    (1998)
  • C. Craig et al.

    In vivo growth factor expansion of endogenous subependymal neural precursor cell populations in the adult mouse brain

    J. Neurosci.

    (1996)
  • L. Crawford et al.

    Localization and release of glutamic acid in relation to the hippocampal mossy fibre pathway

    Nature

    (1973)
  • P. Eriksson et al.

    Neurogenesis in the adult human hippocampus

    Nat. Med.

    (1998)
  • M. Falconer et al.

    Etiology and pathogenesis of temporal lobe epilepsy

    Arch. Neural.

    (1964)
  • J. Franck et al.

    Physiologic and morphologic characteristics of granule cell circuitry in human epileptic hippocampus

    Epilepsia

    (1995)
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