Elsevier

Vitamins & Hormones

Volume 58, 2000, Pages 391-448
Vitamins & Hormones

Steroid/nuclear receptor coactivators

https://doi.org/10.1016/S0083-6729(00)58032-7Get rights and content

Abstract

In higher eukaryotes, steroids/thyroid hormones and many lipophilic compounds regulate cellular physiology through binding to the steroid/nuclear receptor proteins. Steroid/nuclear receptors are ligand-dependent transcriptional activators that can stimulate gene expression. This transcriptional activatons plays a pivotal role in hormone-regulated physiological and pharmacological responses. In recent years, several steroid/nuclear receptor cofactors have been identified and found to interact with the receptor and modulate its transcriptional activity. Among these cofactors, a family of three coactivators has been the focus of intense studies. Although gaps remain, progress has been made in understanding how a given coactivator interacts with the receptor and promotes transcriptional activation. We are beginning to understand coactivator action; for instance, several studies have established the molecular basis of antagonism by anti-hormones and the connection of coactivators with human cancers.

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