Elsevier

The Lancet

Volume 344, Issue 8930, 22 October 1994, Pages 1127-1128
The Lancet

Short reports
Botulinum toxin for chronic anal fissure

https://doi.org/10.1016/S0140-6736(94)90633-5Get rights and content

Abstract

Botulinum toxin can chemically denervate striated muscle. Botulinum toxin A (15 U) was used to treat ten patients with chronic anal fissure by injection in the internal sphincter. In seven patients, the lesion healed at 2 months after treatment; one relapsed at 3 months. In one patient the lesion healed at 1 month, but partly relapsed a month later. Mild faecal incontinence lasting for 1 day was observed in one patient. We propose that botulinum toxin injections in the internal anal sphincter be considered an alternative approach to surgical therapy of anal fissure.

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