Calcium permeability of ligand-gated channels

doi:10.1016/S0143-4160(98)90056-2

Cell Calcium

Volume 24, Issues 5–6, November–December 1998, Pages 325-332

https://doi.org/10.1016/S0143-4160(98)90056-2 Get rights and content

Abstract

Ligand-gated channels activated by excitatory neurotransmitters; glutamate, acetylcholine, ATP or serotonin are cation channels permeable to Ca²⁺. Molecular cloning revealed a large variety of the ligand-gated channel subunits differentially expressed in mammalian brain. Many of them have different Ca²⁺ permeability providing immense diversity in Ca²⁺ entry mediated by ligand-gated channels during synaptic transmission. Functional analysis of cloned channels allowed to identify structural elements in the pore forming regions determining Ca²⁺ permeability for many types of ligand-gated channels. The functional role of the Ca²⁺ entry mediated by various ligand-gated channels in mammalian central nervous system is less understood. The studies reviewed in this article provide information about known structural determinants of Ca²⁺ permeability of the ligand-gated channels and the role of this particular pathway of Ca²⁺ entry in cell function.

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Invited reviewCalcium permeability of ligand-gated channels

Abstract

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Biophys J

FEBS Lett

Neuron

Neurosci Lett

Curr Opin Cell Biol

Neuron

Eur J Pharmacol

Cloned glutamate receptors

Annu Rev Neurosci

N-methyl-D-aspartic acid receptor structure and function

Physioi Rev

A synaptic model of memory: longterm potentiation in the hippocampus

Nature

Calcium permeability of nicotinic acetylcholine receptor channels in bovine adrenal chromaffin cells

Pflüegers Arch

Fractional calcium currents through recombinant GluR channels of the NMDA, AMPA and kainate receptor subtypes

J Physiol

Postsynaptic levels of [Ca2+]i needed to trigger LTD and LTP

Neuron

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J Neurosci

Calcium-mediated modulation of N-methyl-D-aspartate (NMDA) responses in cultured rat hippocampal neurones

J Physiol

Calcium-dependent inactivation of recombinant heteromeric NMDA receptor channels

J Physiol

Kainate-induced inactivation of NMDA currents via an elevation of intracellular Ca2+ in hippocampal neurons

J Neurophysiol

Calcium entry through a subpopulation of AMPA receptors desensitized neighbouring NMDA receptors in rat dorsal horn neurons

J Physiol

Calcium-dependent inactivation of synaptic NMDA receptors in hippocampal neurons

J Neurophysiol

Synaptic desensitization of NMDA receptors by calcineurin

Science

Postsynaptic modulation of NMDA synaptic currents in rat hippocampal microcultures by pairedpulse stimulation

J Physiol

Ca2+-permeable AMPA and NMDA receptor channels in basket cells of rat hippocampal dentate gyrus

J Physiol

Invited review
Calcium permeability of ligand-gated channels

Postsynaptic levels of [Ca²⁺]_i needed to trigger LTD and LTP

Kainate-induced inactivation of NMDA currents via an elevation of intracellular Ca²⁺ in hippocampal neurons

Ca²⁺-permeable AMPA and NMDA receptor channels in basket cells of rat hippocampal dentate gyrus