Synthesis and opioid binding activity of dermorphin analogues containing cyclic β-amino acids
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Long-lasting, distinct changes in central opioid receptor and urinary bladder functions in models of schizophrenia in rats
2011, European Journal of PharmacologyCitation Excerpt :Tyr-Gly-(NMe)PHe-Gly-ol,DAMGO was purchased from Bachem AG (Bubendorf, Switzerland). At the age of week 15 animals were sacrificed, their cerebral cortex and hippocampus were dissected (n = 4/group) and crude membrane fractions were prepared as described earlier (Bozu et al., 1997). Briefly, the brain areas were homogenized in 30 volumes (v/w) of ice-cold 50 mM Tris–HCl pH 7.4 buffer with a teflon-glass Braun homogenizer operating at 1500 rpm.
Pharmacology of a new tritiated endomorphin-2 analog containing the proline mimetic cis-2-aminocyclohexanecarboxylic acid
2011, PeptidesCitation Excerpt :It was also suggested that the incorporation of the cis-(1S,2R)ACPC2 induced low-energy conformations, topologically similar to those calculated for the cis isomer of morphiceptin. We earlier established that the replacement of d-Ala2 by the rigid structure of ACHC2 was unfavorable for opioid binding in the case of another μ-specific peptide ligand, dermorphin (H-Tyr-d-Ala-Phe-Gly-Tyr-Pro-Ser-NH2) [4]. It was hypothesized that the receptor–ligand interactions of the heptapeptide dermorphin derivatives with the μ-opioid receptor are distinct from those of the tetrapeptide morphiceptin.
Detection of a novel immunoreactive endomorphin 2-like peptide in rat brain extracts
2008, Regulatory PeptidesComparison of the separation efficiencies of Chirobiotic T and TAG columns in the separation of unusual amino acids
2004, Journal of Chromatography A