Active efflux by multidrug transporters as one of the strategies to evade chemotherapy and novel practical implications of yeast pleiotropic drug resistance

doi:10.1016/S0163-7258(97)00094-6

Pharmacology & Therapeutics

Volume 76, Issues 1–3, October–December 1997, Pages 219-242

https://doi.org/10.1016/S0163-7258(97)00094-6 Get rights and content

Abstract

Mankind is faced by the increasing emergence of resistant pathogens, including cancer cells. An overview of the different strategies adopted by a variety of cells to evade chemotherapy is presented, with a focus on the mechanisms of multidrug transport. In particular, we analyze the yeast network for pleiotropic drug resistance and assess the potentiality of this system for further understanding of the mechanism of broad specificity and for development of novel practical applications.

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Active efflux by multidrug transporters as one of the strategies to evade chemotherapy and novel practical implications of yeast pleiotropic drug resistance

Abstract

Blood

Parasitol. Today

J. Biol. Chem.

J. Biol. Chem.

Blood

J. Biol. Chem.

Trends Genet.

J. Biol. Chem.

J. Biol. Chem.

Biochem. Biophys. Acta

J. Biol. Chem.

Trends Biotechnol.

J. Biol. Chem.

J. Biol. Chem.

J. Biol. Chem.

Trends Pharmacol. Sci.

FEBS Lett.

J. Biol. Chem.

Cell

Parasitol. Today

Curr. Top. Membr. Transp.

Curr. Genet.

Crit. Rev. Biochem. Mol. Biol.

Cell

Cancer Res.

FEBS Lett.

J. Biol. Chem.

Anticancer Res.

Altered drug sensitivities to anticancer agents in radiation-sensitive DNA repair deficient yeast mutants

Anticancer Res.

Cystic fibrosis transmembrane conductance regulator and adenosine triphosphate

Science

Trends in bacterial resistance to fluoroquinolones

Clin. Infect. Dis.

Regulation of ion channels by ABC transporters that secrete ATP

Science

Multiple efflux mechanisms are involved in Candida albkans fluconazole resistance

Antimicrob. Agents Chemother.

Generation of a drug resistance profile by quantitation of mdr1/P-glycoproetin in the cell lines of the National Cancer Institute anticancer drug screen

J. Clin. Invest.

Isolation and characterisation of SGE1, a yeast gene that partially suppresses the ga111 mutaion in multiple copies

Genetics

Kinase cascades regulating entry into apoptosis

Microb. Mol. Biol. Rev.

Complete restoration of glucocerebrosidase deficiency in gaucher fibroblasts using a bicistronic MDR retrovirus and a new selection strategy

Hum. Gene Ther.

Origin and evolution of genes specifying resistance to macrolide, lincosamide and streptogramin antibiotics; data and hypothesis

J. Antimicrob. Chemother.

Adenosine triphosphate-dependent transport of doxorubicin, daunomycin, and vinblastine in human tissues by a mechanism distinct from the P-glycoprotein

J. Clin. Invest.

Role of glutathjone S-transferase and dinitrophenyl S-glutathione ATPase (Dnp-SG ATPase) in the protection of membranes from xenobiotics and oxidative stress

Int. J. Toxicol. Occup. Environ. Health

Yeast multidrug resistance: the PDR network

J. Bioenerg. Biomembr.

Human somatic gene therapy

Bioessays

Selection for high-level chloroquine resistance results in deamplification of the pfmdrl gene and increased sensitivity to mefloquine in Plasmodium falciparum

EMBO J.

Relationship between the level of minimal inhibitory concentrations of five antiseptics and the presence of qacA gene in Staphylococcus aureus

Pathol. Biol. (Paris)

Candida albieans gene encoding resistance to benomyl and methotrexate is a multidrug resistance gene

Antimicrob. Agents Chemother.

Characterization of the nonenzymatic chloramphenicol resistance (cmlA) gene of the In4 integron of TN1696: similarity of the product to transmembrane transport proteins

J. Bacteriol.

Molecular mechanisms of drug resistance in Mycobacterium tuberculosis

Annu. Rev. Biochem.

Roles of UDP-glucuronyl transferases in chemical carcinogenesis

Crit. Rev. Biochem. Mol. Biol.

Multidrug resistance in Lactococcus lactis: evidence for ATP-dependent drug extrusion from the inner leaflet of the cytoplasmic membrane

EMBO J.

New mechanisms of drug resistance in parasitic protozoa

Annu. Rev. Microbiol.