Journal of the Autonomic Nervous System
Inhibition of potassium and calcium currents in neurones by molecularly-defined P2Y receptors
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Acknowledgements
This work was supported by grants from the Wellcome Trust.
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The role of P2Y<inf>1</inf> receptor signaling in central respiratory control
2016, Respiratory Physiology and NeurobiologyCitation Excerpt :P2Y1 receptors inhibit N-type Ca2+ channels in superior cervical ganglion neurons via the Gαq pathway, but the inhibition is dependent on the βγ- rather than the αq subunit (Herlitze et al., 1996; Ikeda, 1996; Brown et al., 2000; Filippov et al., 2000). Unconventional actions of P2Y1 receptors in NTS neurons through the Gαi pathway produce a βγ-dependent inhibition of N-, P/Q- and L-type Ca2+ channels (Brown et al., 2000; Filippov et al., 2000; Aoki et al., 2004). N- and L-type Ca2+ currents are present in all classes of respiratory neurons while P/Q-type Ca2+ currents are limited to pre-inspiratory neurons and a subset of inspiratory neurons (Onimaru et al., 1996).
P2Y purinergic receptor-regulated insulin secretion is mediated by a cAMP/Epac/Kv channel pathway
2015, Biochemical and Biophysical Research CommunicationsCitation Excerpt :The data are in line with previous findings performed in rat adult ventricle, where Epac activator has been found to prolong action potential duration by decreasing potassium current [19]. In neurons, inhibition of potassium current by stimulating P2YR has also been reported [20]. We thus believe that Kv channel may be the important contributor that mediates P2YR-modulated insulin secretion, which is confirmed by our experiment in insulin secretion assays.
Nucleotides control the excitability of sensory neurons via two P2Y receptors and a bifurcated signaling cascade
2011, PainCitation Excerpt :However, we found no evidence for an induction of chloride currents by any of the nucleotides tested (not shown). The inhibition of KV7 channels by both P2Y1 and P2Y2 has also been observed with receptors heterologously expressed in sympathetic neurons [9]. TRPV1 channels mediate acute and chronic pain [22], and ADP as well as 2-thio-UTP enhanced currents through these receptors; this effect of ADP, but not that of 2-thio-UTP, was again antagonized by MRS 2179.
ATP in central respiratory control: A three-part signaling system
2008, Respiratory Physiology and NeurobiologyInhibitory purinergic P2 receptor characterisation in rat distal colon
2007, NeuropharmacologyCitation Excerpt :MRS2179 also reduced the αβmeATP-induced responses in a concentration range of 1–30 μM, indicating that the selectivity window of this antagonist is limited to concentrations up to 0.3 μM. Correspondingly, Brown et al. (2000a,b) reported MRS2179 to inhibit purinergic responses at cloned rat P2X1 receptors with an IC50 value of 1.15 μM. P2Y1 receptor-induced relaxations are known to involve PLC activation and IP3 generation causing highly directional and localised Ca2+ transients (Ca2+-puffs) from the sarcoplasmic reticulum (SR) that will subsequently initiate an increase in K+ efflux by activation of apamin-sensitive small conductance Ca2+-sensitive K+ (SK) channels, leading to hyperpolarisation and relaxation (Bayguinov et al., 2000; Van Crombruggen and Lefebvre, 2004).