Trends in Pharmacological Sciences
ViewpointNO, nitrosonium ions, nitroxide ions, nitrosothiols and iron-nitrosyls in biology: a chemist's perspective
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2022, Materials Today BioCitation Excerpt :Third, endogenous GSNO was demonstrated to promote the production of vascular endothelial growth factor (VEGF), regulate angiogenesis, and prevent embolization of the vasculature [30–32]. Fourth, GSNO differs from most of the other RSNOs because of its effective direct contribution to the S-nitrosation of enzymes containing sulfhydryl, during which the thiol groups are blocked on the enzymes reversibly [33,34], and lastly GSNO is relatively easier to synthesize and purify [27]. Therefore, GSNO is a desirable agent for endogenous NO production.
The emerging roles of nitric oxide in ferroptosis and pyroptosis of tumor cells
2022, Life SciencesCitation Excerpt :One explanation is that NO molecule generates NO+, which directly forms thiol compound with protein cysteine sulfhydryl group. Another interpretation depends on its role as free radicals [52–54]. In addition to direct reaction, S-nitrosylation is achieved mainly through transnitrosylation because of the instability of NO. The specific process is as follows:
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