Trends in Pharmacological Sciences
Current awarenessCloning of human prostanoid receptors
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Cited by (79)
Pharmacology and perspectives in erectile dysfunction in man
2020, Pharmacology and TherapeuticsCitation Excerpt :TXA2 and PGF2α, through the activation of the TP or FP receptor, and PGE, through EP1 and EP3, mediate the contraction of erectile tissue (Angulo et al., 2002). PGD2, PGE, and PGI2 can induce smooth muscle relaxation (Pierce, Gil, Woodward, & Regan, 1995). The major relaxing prostanoid in corpus cavernosum smooth muscle is PGE (PGE1 and PGE2), which induces relaxation by binding to G-protein-coupled receptors (EP2-EP4) and by increasing cAMP synthesis (Lue & Dahiya, 1997).
Pharmacology of erectile dysfunction in man
2006, Pharmacology and TherapeuticsSpecies differences in the effects of prostanoids on MAP kinase phosphorylation, myosin light chain phosphorylation and contraction in bovine and cat iris sphincter smooth muscle
2005, Prostaglandins Leukotrienes and Essential Fatty AcidsComparison of prostaglandin F<inf>2α</inf>, Bimatoprost (prostamide), and Butaprost (EP<inf>2</inf> agonist) on Cyr61 and connective tissue growth factor gene expression
2003, Journal of Biological ChemistryCitation Excerpt :Activation of FP receptors initiated by ligand binding triggers Gαq protein-coupled mechanisms involved intracellular Ca2+ signaling, IP turnover, and activation of protein kinase C (28). Butaprost is a synthetic prostaglandin analog that interacts with EP2 receptors; it triggers Gαs protein-coupled mechanisms involved in activation of adenylate cyclase and initiation of the cAMP pathway with resultant activation of protein kinase A (29). Despite different intracellular mechanisms, it has been shown that activation of prostaglandin FP or EP2 receptors resulted in lowering intraocular pressure (15, 16).
Pharmacology of functional endogenous IP prostanoid receptors in NCB-20 cells: Comparison with binding data from human platelets
2001, Prostaglandins Leukotrienes and Essential Fatty AcidsThe role of EP 2 receptors in mediating the ultra-long-lasting intraocular pressure reduction by JV-GL1
2021, British Journal of Ophthalmology