Trends in Pharmacological Sciences
Frizzled proteins constitute a novel family of G protein-coupled receptors, most closely related to the secretin family
References (5)
J. Biol. Chem.
(1996)J. Biol. Chem.
(1992)
Cited by (41)
Frizzled receptors (FZD) play multiple cellular roles in development, in diseases, and as potential therapeutic targets
2021, Journal of King Saud University - ScienceFrizzleds as GPCRs – More Conventional Than We Thought!
2018, Trends in Pharmacological SciencesCitation Excerpt :Readouts for FZD activity and ultimately drug discovery will shift from downstream reporter assays to assays directly focusing on receptor activation. The discussion about the GPCR nature of FZDs has continued for almost as long as they have been recognized as 7TM WNT receptors [9,10]. From the view of a pharmacologist, the discussion and the arguments appear unnecessary because biochemical, molecular biological, and pharmacological experimental evidence convincingly identifies FZDs as GPCRs in various cellular and biological systems [2].
Lawsone derivatives target the Wnt/β-catenin signaling pathway in multidrug-resistant acute lymphoblastic leukemia cells
2017, Biochemical PharmacologyCitation Excerpt :Frizzled proteins belong to the G protein-coupled receptor protein family and are characterized by a seven-pass transmembrane structure. They are found in the plasma membranes of Wnt-responsive cells [48]. Recent evidence suggests their internalization as mechanism for regulating the extracellular level of Wnt protein levels [49].
Epithelial G protein-coupled receptor kinases regulate the initial inflammatory response during mycobacterial infection
2013, ImmunobiologyCitation Excerpt :CXCL8 enhances killing of mycobacteria in macrophages and neutrophils (O’Kane et al. 2007; Nibbering et al. 1993) and augmented CXCL8 levels are found in plasma and in bronchoalveolar lavage fluids from patients infected with tuberculosis (Zhang et al. 1995; Meddows-Taylor et al. 1999; Pokkali and Das 2009). G protein-coupled receptors (GPCRs) are important regulators of pulmonary diseases through their binding to a variety of mediators, such as histamine, leukotrienes, prostanoids and chemokines (Barnes et al. 1998). CXCL8 binds to two seven trans-membrane GPCRs, CXCR1 and CXCR2, which are expressed on a variety of cell types and tissues (Baggiolini 2001; Godaly et al. 2000; Schraufstatter et al. 2001).
Parathyroid hormone receptor directly interacts with Dishevelled to regulate β-catenin signaling and osteoclastogenesis
2010, Journal of Biological ChemistryVPAC and PAC receptors: From ligands to function
2009, Pharmacology and Therapeutics