Trends in Neurosciences
Research Focus‘Unfolding’ pathways in neurodegenerative disease
Section snippets
The unfolded-protein response
Eukaryotic organisms have evolved specific signaling pathways to ensure that the protein-folding capacity of the ER is not overwhelmed. Upon accumulation of unfolded proteins the UPR is activated, leading to increased transcription of a characteristic set of genes and to reduced general protein translation. These adaptations have the net effect of reducing the amount of new protein translocated into the ER, increasing degradation of misfolded proteins and enhancing the protein-folding capacity
The UPR and neurodegenerative disease
In addition to Pelizaeus-Merzbacher disease (PMD), the UPR could be involved in the pathogenesis of several neurodegenerative disorders (Fig. 1). In Alzheimer's disease, presenilin 1, the putative γ-secretase necessary for generating Aβ, might be required for the activation and nuclear localization of IRE1 [8], and BiP binds the amyloid precursor protein (APP) in healthy cells, thereby limiting production of Aβ [9]. Moreover, mutations in presenilin 1 associated with familial Alzheimer's
Concluding remarks
In neurodegenerative disorders, the connection between the accumulation of misfolded protein aggregates and disease phenotype is incomplete. In many instances, the accumulation of these abnormal proteins is cytotoxic, owing to the intrinsic deleterious effects of the misfolded disease proteins themselves, the amyloid aggregates they form, or both. However, the direct or indirect activation of the UPR could represent an ‘unfolding’ pathway in disease pathogenesis. Further insights into these
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