Trends in Neurosciences
ReviewWhich GABAA-receptor subtypes really occur in the brain?
References (48)
- et al.
J. Biol. Chem.
(1990) J. Biol. Chem.
(1991)J. Biol. Chem.
(1994)J. Biol. Chem.
(1994)Neuron
(1991)J. Biol. Chem.
(1994)- et al.
J. Biol. Chem.
(1993) - et al.
J. Biol. Chem.
(1995) J. Biol. Chem.
(1994)Eur. J. Pharmacol.
(1995)
Neuron
J. Biol. Chem.
Neuroscience
Neuroscience
Neuroscience
FEBS Lett.
Genomics
Neuron
Genomics
Genomics
Nature
Nature
J. Neurochem.
J. Neurochem.
Cited by (1096)
Development and validation of LC–MS/MS methods for the determination of EVT201 and its five metabolites in human urine: Application to a mass balance study
2023, Journal of Chromatography B: Analytical Technologies in the Biomedical and Life SciencesHippocampal α5-GABA<inf>A</inf> Receptors Modulate Dopamine Neuron Activity in the Rat Ventral Tegmental Area
2023, Biological Psychiatry Global Open ScienceDevelopment of a Kilogram-Scale Route for Clinical Sample Production of the Intravenous Anesthetic Cipepofol
2022, Organic Process Research and DevelopmentGABRB2, a key player in neuropsychiatric disorders and beyond
2022, GeneCitation Excerpt :Amino acid residues of TM2 from each subunit contribute to the ion channel. The most abundant subtype accounting for 43% of all GABAA receptors in the adult brain displays γβαβα subunit arrangement in an anti-clockwise direction (Fig. 1B) (Baumann et al., 2002; Cheng et al., 2009; Hirose, 2014; McCracken et al., 2010; McKernan and Whiting, 1996). The γ subunit-containing GABAA receptors ensure a phasic inhibition at the postsynaptic sites whereas the δ subunit-containing ones sustain tonic inhibition at the extrasynaptic sites (Hartiadi et al., 2016; Hirose, 2014; Wei et al., 2003).
- 1
Ruth M. McKernan and Paul J. Whiting are at the Dept of Biochemistry and Molecular Biology, Neuroscience Research Centre, Merck Sharp and Dohme Research Laboratories, Terlings Park, Eastwick Rd, Harlow, Essex, UK CM20 2QR.