Estrous cycle-dependent variation in amphetamine-induced behaviors and striatal dopamine release assessed with microdialysis

doi:10.1016/S0166-4328(89)80112-3

Behavioural Brain Research

Volume 35, Issue 2, 1 November 1989, Pages 117-125

https://doi.org/10.1016/S0166-4328(89)80112-3 Get rights and content

Estrous cycle-dependent variation in amphetamine (AMPH)-stimulated behaviors and striatal dopamine (DA) release were determined for freely moving rats undergoing intracerebral microdialysis. There was greater AMPH-stimulated striatal DA release in the striatum of rats in estrus, during the period from 20 min to 100 min post-AMPH, compared with the response of rats in diestrus (P<0.05). Animals in estrus also showed less general activity and greater intensity of stereotyped behaviors than did animals in diestrus (P<0.05). Independent experiments examining estrous cycle-dependent differences in AMPH-stimulated striatal DA release in vitro also found that AMPH-stimulated striatal DA release was greater on estrus than on diestrus (P<0.05). Thus, striatal DA release and behaviors induced by AMPH are modulated by ovarian hormones. The heightened responsiveness to AMPH during estrus suggests that estrogen and/or progesterone potentiate the striatal DA response to AMPH.

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Estrous cycle-dependent variation in amphetamine-induced behaviors and striatal dopamine release assessed with microdialysis

Horm. and Behav.

Behav. Brain Res.

Brain Res.

Eur. J. Pharmacol.

J. Neurosci. Methods

Pharmacol. Biochem. Behav.

Behav. Neural Biol.

Life Sci.

Neuropharmacology

Brain Res.

Life Sci.

Eur. J. Pharmacol.

Pharmacol. Biochem. Behav.

Pharmacol. Biochem. Behav.

Pharmacol. Biochem. Behav.