Improvement of sleep quality by controlled-release melatonin in benzodiazepine-treated elderly insomniacs
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2017, Best Practice and Research: Clinical Endocrinology and MetabolismCitation Excerpt :Agomelatin, an MLT receptor targeting anti-depressant drug is also known to act on the sleep wake cycle [95]. A prolonged-release MLT formulation (circadin) has also been approved for marketing in Europe for insomnia therapy [96]. As the chronobiotic effect of MLT is mediated through the MT1 receptor subtype pharmacological/chemical investigations should aim to develop selective agonists (and antagonists) for this subtype.
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2013, Experimental NeurologyCitation Excerpt :Melatonin might also be useful. Melatonin is a neurohormone that has been shown to improve sleep disturbances in the elderly (Garfinkel et al., 1997) as well as in PD (Dowling et al., 2005), and again, although its efficacy is not well established, it is unlikely to have deleterious side effects in HD patients. Environmental enrichment and brain training has been shown to improve a number of aspects of disease progression including cognitive function in HD mice (Carter et al., 2000; Hockly et al., 2002; Wood et al., 2010, 2011).
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