Signal transduction through NF-κB

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Abstract

The inducible transcription factor NF-κB plays a central role in the regulation of many immune and inflammatory responses. Advances in our knowledge of the signaling mechanisms that control the activation of NF-κB and recent insights into the nature of the IκB-kinase represent significant steps forward in understanding this important signaling pathway.

Keywords

immune activation
inflammation
signaltrandsuction
transcription factor
IκB-kinase
inducible gene transcription
NF-κB
transcription
IκB

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