Rapid communicationFunctional expression of GABA ϱ 3 receptors in Xenopus oocytes
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GABAρ selective antagonist TPMPA partially inhibits GABA-mediated currents recorded from neurones and astrocytes in mouse striatum
2017, NeuropharmacologyCitation Excerpt :Previous studies reported the expression of GABAρ1 and GABAρ2 in adult neostriatum but did not explore the expression of GABAρ3 (Rosas-Arellano et al., 2012). This subunit also does not show desensitization upon activation by the agonist, nor is it modulated by pentobarbital (Shingai et al., 1996). Thus, we sought to determine whether GABAρ3 is expressed in interneurons or astrocytes from the neostriatum.
Persistent GABA<inf>A/C</inf> responses to gabazine, taurine and beta-alanine in rat hypoglossal motoneurons
2016, NeuroscienceCitation Excerpt :Nevertheless, in the hippocampus, the TPMPA applications performed in the absence of SR did not exclude a possible contribution of ρ-subunits to the current activated by SR. Steroids known to potentiate GABAA responses, such as allopregnanolone or alphaxalone, only potentiate responses of recombinant homomeric human ρ1 receptors when applied at high concentrations (Morris et al., 1999) and do not affect rat ρ3 receptors up to 1 μM (Shingai et al., 1996). Similarly, native GABAC receptors in rat bipolar cells are insensitive to low concentrations of alphaxalone (Feigenspan et al., 1993).
Emerging Molecular Mechanisms of Signal Transduction in Pentameric Ligand-Gated Ion Channels
2016, NeuronCitation Excerpt :Since the first isolation of nAChRs, more than 40 genes coding for vertebrate pLGIC subunits have been identified and grouped into distinct families, according to their neurotransmitter pharmacology (Dent, 2010): the nAChRs (with 17 known subunits termed α1−α10, β1−β4, γ, δ, and ε), the 5-HT3Rs (with 5 known subunits termed A–E), the GABAARs (with 19 known subunits termed α1−α6, β1−β3, γ1−γ3, δ, ε, θ, π, and ρ1−ρ3), the GlyRs (with 5 known subunits termed α1−α4 and β), and a single zinc-activated channel subunit (Figure 1). A minority of subunits can form functional homopentamers; α7- and α9-nAChRs (Couturier et al., 1990; Elgoyhen et al., 1994); the 5-HT3A receptor (Maricq et al., 1991); α1-, α2-, and α3-GlyRs (Grenningloh et al., 1990; Kuhse et al., 1990; Schmieden et al., 1989); and ρ1-, ρ2-, and ρ3-GABAARs (Cutting et al., 1991; Kusama et al., 1993; Shingai et al., 1996). Some of these subunits can sometimes assemble with other subunits, as illustrated by α9α10-nAChRs (Elgoyhen et al., 2001), 5-HT3AB receptors (Davies et al., 1999), and α1β-GlyRs (Langosch et al., 1988).
Ionotropic GABA receptors with mixed pharmacological properties of GABA <inf>A</inf> and GABA <inf>C</inf> receptors
2004, European Journal of PharmacologyGABA<inf>A</inf> receptor subunit mRNA expression in cultured embryonic and adult human dorsal root ganglion neurons
2004, Developmental Brain ResearchCitation Excerpt :Thus it might be proposed that a ρ containing receptor is responsible for our observations. We did not assay for the expression of ρ3 RNA (see Materials and methods) and no information is available regarding the picrotoxin sensitivity of human ρ3 containing receptors; however, receptors formed by rat ρ3 are highly sensitive to picrotoxin with an IC50 of less than 1 μM at 100 μM GABA [18]. We found no evidence of ρ2 expression in any of the embryonic or adult cultures, suggesting that this subunit is not responsible for the novel pharmacology observed in adult neurons.