Journal of the American Academy of Dermatology
Drug-induced linear IgA bullous dermatosis after vancomycin discontinuance in a patient with renal insufficiency☆,☆☆,★
Section snippets
CASE REPORT
A 65-year-old man was admitted to Kings Daughters Hospital (Madison, Ind) after an acute anteroseptal myocardial infarction. He was subsequently transferred to Jewish Hospital (Louisville, Ky) for evaluation for cardiac surgery. His past medical history included a previous myocardial infarction, hypertension, hypercholesterolemia, and chronic obstructive pulmonary disease. Medications on admission were clonidine hydrochloride and hydrochlorothiazide.
Three days after transfer, he underwent an
DISCUSSION
LABD is an autoimmune subepidermal vesiculobullous disease that is characterized histopathologically by the linear deposition of IgA at the BMZ. Multiple medications have been implicated as potential etiologies of drug-induced LABD (Table II).5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30
We report a 65-year-old man with sepsis and renal failure, who developed LABD 14 days after receiving his last dose of vancomycin. Of 8 reported cases, all but
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Cited by (58)
Immune-mediated reactions to vancomycin A systematic case review and analysis
2016, Annals of Allergy, Asthma and ImmunologyLinear immunoglobulin A bullous dermatosis
2012, Clinics in DermatologyCitation Excerpt :All of these characteristics, along with a time relation to ingestion of a drug and the very rare presence of circulating anti-BMZ IgA antibodies in the drug-induced vs idiopathic form, might be useful for differentiating the idiopathic from the drug-induced form.102 The most common drug reported from 1981 to 2010 to be related with LAD was vancomycin,103-111 followed by amiodaron,104 diclofenac,112 captopril,113 ceftriaxone-metronidazole,114 naproxen,115 piroxicam,116 and pheynotin.117 The pathophysiologic mechanism of drug-induced LAD still remains largely unknown.
A histologic review of vulvar inflammatory dermatoses and intraepithelial neoplasm
2010, Dermatologic ClinicsCitation Excerpt :They are usually pruritic and become ulcerated and crusted within 24 hours. The eruption can be preceded by a bacterial or viral infection50,51 or it is drug induced, often by vancomycin.52 A subepidermal blister containing neutrophils is seen.
The vesiculobullous reaction pattern
2009, Weedon's Skin Pathology: Third EditionOcular Manifestations of Blistering Diseases
2008, Immunology and Allergy Clinics of North AmericaCitation Excerpt :Adult patients experience less frequent (48%) remission and a more prolonged disease course lasting an average of 5 to 6 years [61–66]. Drug-induced cases typically resolve quickly with identification and withdrawal of the offending agent [67–73]. Although ocular and oral lesions may leave persistent scarring as in the case with MMP, cutaneous lesions usually heal without scarring.
Cutaneous drug reactions induced by glycopeptides
2007, Medecine et Maladies Infectieuses
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