Structure-activity relationship studies on (4-acylpyrrol-2-yl)alkanoic acids as inhibitors of the cytosolic phospholipase A2: Variation of the alkanoic acid substituent, the acyl chain and the position of the pyrrole nitrogen
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Pyrrole alkanoic acid derivatives as nuisance inhibitors of microsomal prostaglandin E <inf>2</inf> synthase-1
2012, European Journal of Medicinal ChemistryCitation Excerpt :For the synthesis of numerous of the dodecanoyl-substituted target compounds (35,43–45,55–67,75) similar synthetic routes were applied as for the preparation of their known corresponding octadecanoyl and octadecyl derivatives, respectively [35,36,38,39]. The benzoyl and 2-naphthoyl substituted pyrrolylpropionic acid derivatives 28 and 30 were synthesized starting from methyl 3-(1,3,5-trimethylpyrrol-2-yl)propionate according to the procedure published for the preparation of 12 [35]. The remaining compounds of this series (17,20,26,27,29,32–33) were prepared from ethyl 1,3,5-trimethylpyrrol-2-carboxylate in an analogous manner as shown in Scheme 1 for the synthesis of 26.
Thermodynamic characterization of cytosolic phospholipase A<inf>2</inf> alpha inhibitors
2008, Analytical BiochemistryPasserini/tsuji–trost strategy towards pyrrole derivatives
2017, European Journal of Organic Chemistry
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