PaperSize effect on systemic and mucosal immune responses induced by oral administration of biodegradable microspheres
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2024, Applied Surface Science AdvancesDevelopment of a solid dosage platform for the oral delivery of bilayer vesicles
2017, European Journal of Pharmaceutical SciencesCitation Excerpt :After freeze-drying within the capsules, the contents were rehydrated with 0.5 mL ultrapure water, vortexed and then analysed for vesicle size and charge. The vesicles from the capsules reduced in size to an average of 4 to 5 μm with the zeta potential remaining highly negative (Fig. 5) which is within the size range suitable for uptake by the Peyer's patches (Tabata and Ikada, 1988; Ebel, 1990; Eldridge et al., 1990; Tabata et al., 1996). Similarly, antigen loading within the vesicles was compared across all 3 dosage form platforms (liquid, freeze-dried capsules and ODT).
Development of a single-dose recombinant CAMP factor entrapping poly(lactide-co-glycolide) microspheres-based vaccine against Streptococcus agalactiae
2017, VaccineCitation Excerpt :Various studies have demonstrated that particle size greatly affects vaccine immunogenicity [38,41], although no clear conclusions have been drawn. Particles with a diameter <5 μm induced a stronger humoral systematic reaction than particles >5 μm [42]. Similarly, a recent report that the smaller PLGE MS (<10 μm) entrapped with staphylococcal enterotoxin B toxoid had better immunogenicity than larger particles (10–110 μm) [43].
Orchestrating immune responses: How size, shape and rigidity affect the immunogenicity of particulate vaccines
2016, Journal of Controlled ReleaseCitation Excerpt :The type of DC to which the antigen is delivered may influence the skewing of the immune response, but this is outside the scope of this review [40]. A study using orally dosed biodegradable polylactic acid (PLA) microparticles ranging from 1 to 26 μm in diameter showed that the uptake of these particles into intestinal lymphoid structures referred to as Peyer's patches, increased with increasing particle size up to 11 μm, and decreased again hereafter [41]. Microspheres smaller than 5 μm were subsequently translocated via the lymphatic system from the Peyer's patches to the spleen, whereas larger particles remained in the Peyer's patches in the jejunum.