Research sectionA single amino acid substitution (Leu160His) in cytochrome P450 CYP2A6 causes switching from 7-hydroxylation to 3-hydroxylation of coumarin
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Cited by (101)
Functional characterization of 9 CYP2A13 allelic variants by assessment of nicotine C-oxidation and coumarin 7-hydroxylation
2018, Drug Metabolism and PharmacokineticsHow can we Improve on Modeling Nicotine Addiction to Develop Better Smoking Cessation Treatments?
2016, International Review of NeurobiologyCitation Excerpt :Altered activity of CYP2A6 would clearly affect the bioavailability of nicotine in the systemic circulation and therefore would be a key factor involved with the addictive properties of nicotine itself. Several genetic single nucleotide polymorphisms (SNPs) have been identified that reduce function of CYP2A6*2, *4, and *5, which would lead to a prolonged effect of nicotine in the body, as well as increased gene replication of CYP2A6 in some individuals which would lead to lower sensitivity to the effects of nicotine (Ariyoshi, Sawamura, & Kamataki, 2001; Benowitz, Tyndale, Jacob, & Swan, 2002; Hadidi, Zahlsen, Idle, & Cholerton, 1997; Tyndale & Sellers, 2001). SNPs in the choline acetyltransferase (ChAT) gene (rs1880676, rs3810950, and rs868750) were also significantly associated with level of nicotine dependence (allele p-values were 0.01, 0.02, and 0.04, respectively).
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On sabbatical leave from the Jordan University of Science and Technology, Irbid, Jordan.