Chronic treatment with certain antipsychotic drugs preserves upregulation of regulator of G-protein signalling 2 mRNA in rat striatum as opposed to c-fos mRNA
References (16)
Emerging roles for RGS proteins in cell signalling
Trends Pharmacol. Sci.
(1999)- et al.
Differential expression of inducible transcription factors in basal ganglia neurons
Brain Res. Mol. Brain Res.
(1995) - et al.
Differential effects of acute and chronic treatment with typical and atypical neuroleptics on c-fos mRNA expression in rat forebrain regions using non-radioactive in situ hybridization
Neurochem. Int.
(1999) G-protein signaling: satisfying the basic necessities of life
Curr. Biol.
(2000)- et al.
Regulators of G protein signaling: rapid changes in mRNA abundance in response to amphetamine
J. Neurochem.
(1998) - et al.
RGS mRNA expression in rat striatum: modulation by dopamine receptors and effects of repeated amphetamine administration
J. Neurochem.
(1999) Regulators of G protein signaling: A bestiary of modular protein binding domains
J. Neurochem.
(2000)Atypical antipsychotics: an inspiring but confusing concept
Psychopharmacology (Berl.)
(2000)
Cited by (20)
RGS2 promotes formation of neurites by stimulating microtubule polymerization
2006, Cellular SignallingAltered expression of regulators of G-protein signaling (RGS) mRNAs in the striatum of rats undergoing dopamine depletion
2003, Biochemical PharmacologyCitation Excerpt :While some of them—mainly RGS2—are now well characterized for their acute regulation by a variety of drugs (including dopamine receptor antagonists, amphetamine and opioids) [16–23], their modulation after long-term injury or chronic pharmacological treatments remains poorly described. Recent papers, particularly concerning the central dopamine system, suggest a potential role of RGS proteins in long-term adaptation processes observed in response to pharmacological treatment [24,25] or occurring during the development of neurodegenerative diseases [26]. In the present study we have used in situ hybridization to measure the mRNA levels of several RGS proteins in the striatum of rats after either 6-hydroxydopamine-mediated denervation of the nigrostriatal pathway or reserpine-induced monoamine depletion.