Functional role of inducible nitric oxide synthase on mouse colonic motility
Section snippets
Acknowledgements
The financial support of Telethon - Italy (Grant no. 1264 to G.B.A.) is gratefully acknowledged.
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Neostigmine-induced contraction and nitric oxide-induced relaxation of isolated ileum from STZ diabetic guinea pigs
2011, Autonomic Neuroscience: Basic and ClinicalCitation Excerpt :Since prolonged suppression of nNOS by exogenous administration of 7-nitroindazole resulted in upregulation of intestinal iNOS mRNA, protein, and activity (Qu et al., 2001), one could speculate that diabetes-induced decrease in nNOS mRNA, protein, and enzyme activity (Martinez-Cuesta et al., 1995; Takahashi et al., 1997; Watkins et al., 2000; Cellek et al., 2003; Surendran and Kondapaka, 2005; Shotton and Lincoln, 2006; Zandecki et al., 2008) may result in upregulation of iNOS mRNA, protein, and activity. A physiologic role for iNOS in peristalsis of normal mouse colon has been proposed (Mancinelli et al., 2001); however, additional experiments using many NOS inhibitors with different selectivities for nNOS and iNOS are required to fully explore a physiologic role for iNOS in smooth muscle relaxation in diabetic animals. In general, ilea recovered better from l-arginine (3–30 mM) (Fig. 8A) than SNP (0.3–300 μM) (Fig. 8C) induced relaxations even though the magnitudes of smooth muscle relaxations were similar (Fig. 6).
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