Injection of orphanin FQ/nociceptin into the periaqueductal gray suppresses the forebrain-elicited vocalization in the guinea pig
Section snippets
Acknowledgements
The authors appreciate the Narishige Neuroscience Research Foundation and Grant D from the Kansai Medical University.
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2013, Neurology Psychiatry and Brain ResearchCitation Excerpt :The PAG, in turn, is broadly involved in emotional and pain-related processing,26–28 has been implicated in anxiety as well as panic,29–31 and mediates the control of emotionally driven motor responses,32,33 including guinea pig separation vocalizations.33,34 Earlier studies of brain stimulation in guinea pigs utilized acute stimulation protocols, often with anesthetized animals.11,13,35,36 To date, the effect of repeated stimulation of vocalization-producing brain regions in guinea pigs has not been examined.
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2010, Behavioural Brain ResearchCitation Excerpt :These data suggest that the dPAG may be involved in the modulation of the behavioural responses triggered by the ACC. Vocalisation responses, for example, elicited by electrical stimulation of the ACC, may be abolished by administration of an NMDA antagonist into the PAG [31]. Since the dPAG is activated by ACC stimulation, it is reasonable to hypothesise that it contributes to diminishing the TI response by recruiting the more caudal substrates in the medullary region, such as the nucleus raphe magnus (NRM), for instance.
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