Intracerebroventricular administration of nocistatin reduces inflammatory hyperalgesia in rats
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Cited by (30)
Pain Regulation by Nocistatin-Targeting Molecules: G Protein-Coupled-Receptor and Nocistatin-Interacting Protein
2015, Vitamins and HormonesCitation Excerpt :Furthermore, the i.c.v. administration of NST reverses N/OFQ-induced biological activities such as hyperalgesia, anti-opioid analgesia (Liu, Nishiuchi, Kimura, & Tachibana, 2006; Scoto, Santangelo, & Parenti, 2005; Zhao et al., 1996), impairment of learning and memory (Hiramatsu & Inoue, 1999), anxiolytic and anxiogenic actions (Gavioli, Rae, Calo, Guerrini, & de Lima, 2002; Kamei, Matsunawa, Miyata, Tanaka, & Saitoh, 2004), and an increase in food intake (Olszewski, Shaw, Grace, Billington, & Levine, 2000). NST has no effects under physiologically normal conditions, but NST itself has inhibitory effects on inflammatory pain responses induced by formalin and carrageenan/kaolin (Nakagawa, Kaneko, Inamura, & Satoh, 1999; Nakano et al., 2000; Yamamoto & Sakashita, 1999), hyperalgesia in chronic constriction injury (CCI) to the sciatic nerve, and morphine tolerance (Ge et al., 2007; Sun et al., 2001). NST at high doses (nmol) has also been reported to induce pronociceptive effects on the inflammatory pain response by formalin (Ahmadi et al., 2003; Zeilhofer, Selbach, Gühring, Erb, & Ahmadi, 2000), hyperalgesia in CCI, and nociceptive flexor reflexes (Inoue, Kawashima, Allen, & Ueda, 2003).
Identification of NIPSNAP1 as a nocistatin-interacting protein involving pain transmission
2012, Journal of Biological ChemistryCitation Excerpt :Although NST does not interfere with the binding of N/OFQ to NOP or N/OFQ-induced intracellular signaling in vitro, it blocks N/OFQ-induced pain transmission in vivo (8). NST itself exerts inhibitory effects, such as inflammatory pain responses (11–13) and morphine tolerance (14, 15). NST also induces pronociceptive effects in inflammatory pain response at high doses (nmol) (16, 17) and nociceptive flexor reflexes (18).
Effects of intraplantar Nocistatin and (±)-J 113397 injections on nociceptive behavior in a rat model of inflammation
2012, Pharmacology Biochemistry and BehaviorCitation Excerpt :Moreover, NST reversed the effect of i.t. N/OFQ on thermal hyperalgesia induced by inflammatory pain conditions in rats (Ma et al., 2003). The spinal injection of NST diminished the flinching behavior in phase 1, but not phase 2, of the formalin test in rats (Yamamoto and Sakashita, 1999), while supraspinal injection of the peptide has an antihyperalgesic effect on the inflammatory hyperalgesia induced by carrageenan/kaolin (Nakagawa et al., 1999) and reversed the nociceptive effect of N/OFQ and its antagonistic effect against analgesia caused by the selective opioid agonists (Scoto et al., 2005). NST, however, does not displace [3H]N/OFQ-binding (Nicol et al., 1998) or attenuate N/OFQ inhibition of forskolin-induced cAMP accumulation in cells transfected with the NOP receptor (Okuda-Ashitaka et al., 1998) and neither mimics nor blocks NOP receptor-mediated Ca2+ current inhibition (Connor et al, 1999).
Nocistatin excites rostral agranular insular cortex-periaqueductal gray projection neurons by enhancing transient receptor potential cation conductance via G<inf>αq/11</inf>-PLC-protein kinase C pathway
2010, NeuroscienceCitation Excerpt :Supraspinal administration of N/OFQ induces a hyperalgesic effect and inhibits opioid receptor-mediated analgesia (Mogil and Pasternak, 2001). In contrast, i.c.v. application of NST attenuates inflammatory hyperalgesia and blocks N/OFQ-induced supraspinal pronociceptive effect (Okuda-Ashitaka et al., 1998; Nakagawa et al., 1999; Liu et al., 2006). A high level of prepronociceptin/orphanin FQ mRNA and NOP receptor mRNA is expressed in RAIC (Anton et al., 1996; Boom et al., 1999; Witta et al., 2004).
Nocistatin and nociceptin exert opposite effects on the excitability of central amygdala nucleus-periaqueductal gray projection neurons
2009, Molecular and Cellular Neuroscience