Prostaglandins, Leukotrienes and Essential Fatty Acids
Original articleArachidonylethanolamide (anandamide) binds with low affinity to dihydropyridine binding sites in brain membranes
References (17)
- et al.
Fatty acid amides of ethanolamine in mammalian tissues
J Biol Chem
(1965) - et al.
N-Acylated glycerophospholipids and their derivatives
Prog Lipid Res
(1990) - et al.
Isolation, identification and synthesis of an endogenous arachidonic amide that inhibits calcium channel antagonist 1,4-dihydropyridine binding
Prostaglandins Leukot Essent Fatty Acids
(1993) - et al.
Effects of anandamide and arachidonic acid on specific binding of (+) PN-200-110, diltiazem and (−) desmethoxyverapamil to L-type Ca2+ channel
Eur J Pharmacol
(1996) - et al.
Enzymatic synthesis and degradation of anandamide, a cannabinoid receptor agonist
Biochem Pharmacol
(1993) - et al.
Characterization of the kinetics and subcellular distribution of arachidonylethanolamide (anandamide) hydrolase of rat brain
Biochim Biophys Acta
(1995) - et al.
Anandamide amidohydrolase activity in rat brain microsomes
J Biol Chem
(1995) - et al.
Effects of anandamide on cannabinoid receptors in rat brain membranes
Biochem Pharmacol
(1994)
Cited by (24)
Anandamide inhibits FcεRI-dependent degranulation and cytokine synthesis in mast cells through CB<inf>2</inf> and GPR55 receptor activation. Possible involvement of CB<inf>2</inf>-GPR55 heteromers
2018, International ImmunopharmacologyCitation Excerpt :Although many endocannabinoid effects in immune cells are mediated by CB1 and CB2 receptors [11,12], some others are not [13]. In particular, AEA blocks T-type and L-type Ca2+ channels [14,15], acts as a partial TRPV1 agonist [16], and activates PPAR [17] and GPR55 receptors [18]. Mast cells (MCs) have an important role in the physiopathology of inflammation [19,20].
Regulation of voltage-gated Ca<sup>2+</sup> channels by lipids
2009, Cell CalciumPharmacological characterization and appetite suppressive properties of BMS-193885, a novel and selective neuropeptide Y<inf>1</inf> receptor antagonist
2008, European Journal of PharmacologyReceptor-independent actions of cannabinoids on cell membranes: Focus on endocannabinoids
2006, Pharmacology and TherapeuticsEffects of saturated long-chain N-acylethanolamines on voltage-dependent Ca <sup>2+</sup> fluxes in rabbit T-tubule membranes
2005, Archives of Biochemistry and BiophysicsCitation Excerpt :In an earlier investigation, Gulaya et al. [22] measured Rb+ efflux through veratridine-activated Na+ channels in neuroblastoma cells and showed that in the concentration range of 0.5–5 μM, long-chain NAEs (C: 14 to C: 18) inhibit the function of Na+ channels significantly. In another study, NAEs including palmitoylethanolamide, linolenylethanolamide, and docosatetraenylethanolamide were found to be ineffective on specific binding of [3H]Isradipine on neuronal VDCCs from brain cortex membranes [23]. In this study, however, albumin, which binds fatty acids [25] and fatty acid amides effectively [26], was included (1 mg/ml).
Effect of arvanil (N-arachidonoyl-vanillyl-amine), a nonpungent anandamide-capsaicin hybrid, on ion currents in NG108-15 neuronal cells
2003, Biochemical PharmacologyCitation Excerpt :Therefore, the blockade of ion currents by arvanil observed in NG108-15 cells appears to be direct and relatively selective for L-type Ca2+ channels. Arvanil may interact with L-type Ca2+ channels at the 1,4-dihydropyridine binding site, since this seems to be the case for anandamide, which is structurally related to arvanil [2,5,12–14]. However, the binding domain for this compound remains to be further characterized.