Potassium ion channels and human disease: phenotypes to drug targets?
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Cited by (41)
Localization and Targeting of GIRK Channels in Mammalian Central Neurons
2015, International Review of NeurobiologyCitation Excerpt :Ion channels are classified by their gating properties and ion selectivity for Na+, Ca2 +, Cl−, and K+ (Hille, 2001). Potassium (K+)-selective channels are key determinants of membrane excitability and regulate a variety of cellular processes including membrane potential, signal transduction, hormone release, vascular tone, cell volume, and immune responses (Curran, 1998). Four different subfamilies of K+ channels have been proposed based on their structural and phylogenetic relationship: voltage-gated K+ (Kv) channels, Ca2 +-activated K+ (KCa) channels, two-pore K+ (K2P) channels, and inwardly rectifying (Kir) channels (Gutman et al., 2005).
A cell-based impedance assay for monitoring transient receptor potential (TRP) ion channel activity
2011, Biosensors and BioelectronicsCitation Excerpt :The applied microelectrodes are often non-transparent and do not allow microscopic imaging of the adherent cells. Ion channel characterisation using cell-based impedance spectroscopy is rarely found in the literature, although ion channels located in cell membranes have crucial roles in physiology and pathophysiology and are important targets for drug discovery (Curran, 1998; Wissenbach et al., 2004; Okuhara et al., 2007; Jegla et al., 2009; Patapoutian et al., 2009; Mathie, 2010; Nassini et al., 2010). Impedimetric single cell analysis of ion channel activity in bovine chromaffin cells might serve as a rare example (Han and Frazier, 2006) where the observed impedance changes could be directly attributed to a molecular compound within the cell membrane.
Cloning and characterization of BmK86, a novel K<sup>+</sup>-channel blocker from scorpion venom
2007, Biochemical and Biophysical Research CommunicationsCitation Excerpt :K+ channels play a key role in cellular excitability and signal transduction. Exploring their structure and function has led to the design of many therapeutic compounds [23,24]. To obtain yet more useful tools for K+-channel studies, it is important to continue the search for new and specific toxins.
Chronic inhibition of cardiac Kir2.1 and hERG potassium channels by celastrol with dual effects on both ion conductivity and protein trafficking
2006, Journal of Biological Chemistry