Synaptic vesicle endocytosis

doi:10.1016/S0959-4388(97)80059-1

Current Opinion in Neurobiology

Volume 7, Issue 3, June 1997, Pages 323-330

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Abstract

Exocytosis of synaptic vesicles is followed rapidly by reinternalization and recycling of their membranes. Recent studies have confirmed the key role of clathrin-mediated endocytosis in synaptic vesicle reformation and have identified new proteins that participate in this process. In addition, growing evidence suggests that lipids, primarily phosphoinositides, play an important role in synaptic vesicle recycling.

Abbreviations

AP adaptor protein

ARF ADP-ribosylation factor

EGF epidermal growth factor

InsP₃ inositol trisphosphate

InsP₄ inositol tetraphosphate

PH pleckstrin homology

PI phosphoinositide

Ptdlns(4,5)P₂ phosphatidyl inositol biphosphate

Ptdlns(3,4,5)P₃ phosphatidyl inositol trisphosphate

SH Src homology

SV synaptic vesicle

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¹: Permanent address: Department of Medical Sciences, II Faculty of Medicine, University of Torino, Via Solaroli 17, 21100 Novara, Italy