The Journal of Steroid Biochemistry and Molecular Biology
Sex differences in the regulation of embryonic brain aromatase*
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Cited by (46)
A neural circuit perspective on brain aromatase
2022, Frontiers in NeuroendocrinologyCitation Excerpt :For this, we turn now to evidence of sex and species differences in aromatase expression, function, and distribution. Aromatase neurons play key roles in sexual differentiation during development and contribute to sex differences in adulthood (Steinach et al., 1936; Naftolin et al., 1975; Balthazart and Foidart, 1993; Hutchison et al., 1997; McCarthy et al., 2006; Bergan et al., 2014; Södersten et al., 2014; Unger et al., 2015; Billing et al., 2020; Cornil et al., 2020). How neuroestrogen production may organize the early sexual differentiation of the brain as well as contribute to the emergence of sex differences in brain functions during adulthood are still far from settled.
Sex chromosome complement determines sex differences in aromatase expression and regulation in the stria terminalis and anterior amygdala of the developing mouse brain
2015, Molecular and Cellular EndocrinologyMechanisms of crosstalk between endocrine systems: Regulation of sex steroid hormone synthesis and action by thyroid hormones
2014, General and Comparative EndocrinologyUnexpected gender difference in sensitivity to the acute toxicity of dioxin in mice
2012, Toxicology and Applied PharmacologyCitation Excerpt :In the mouse testis, testosterone accounts for over 70% of the total steroids produced following maximal stimulation by the luteinizing hormone (Chubb and Desjardins, 1983). The androgenic action of it or of its more potent metabolite formed in many target tissues, 5α-dihydrotestosterone, is mediated by the androgen receptor (AR) except for bone, brain and white adipose tissue, where the estrogen receptor (ER) also contributes after the conversion of testosterone to 17β-estradiol by aromatase (CYP19) (Hutchison et al., 1997; Mayes and Watson, 2004; Vanderschueren et al., 2008). The ovarian hormones 17β-estradiol and progesterone exert their actions on target cells predominantly through the binding and activation of the intracellular receptors ER and progesterone receptor (PR), respectively.
Neuroendocrine inherited or induced aromatase enzyme deficits
2012, Handbook of NeuroendocrinologyEffect of low dose exposure to the herbicide atrazine and its metabolite on cytochrome P450 aromatase and steroidogenic factor-1 mRNA levels in the brain of premetamorphic bullfrog tadpoles (Rana catesbeiana)
2011, Aquatic ToxicologyCitation Excerpt :Mechanistically, estrogens and THs influence each other leading to complex regulatory possibilities (Vasudevan et al., 2002). A pivotal enzyme required in estrogen production is cytochrome P450 aromatase (CYP19) which catalyzes conversion of testosterone to estradiol thereby contributing to a variety of hormone-dependent processes that include sexual differentiation, behavior, neural development, neuroprotection, and regulation of neurotransmitter receptor function (Hutchison et al., 1997; Li and Shen, 2005; Piferrer and Blazquez, 2005). The nuclear transcriptional regulatory factor steroidogenic factor-1 (SF-1), also known as adrenal 4 binding protein (Ad4BP), regulates CYP19 expression, and both are expressed in amphibian brain tissue (Mayer et al., 2002; Kuntz et al., 2004; Kloas et al., 2009).
- *
Proceedings of the IV International Aromatase Conference, Tahoe City, CA, U.S.A., 7–11 June 1996.