Adenosine A2A antagonists with potent anti-cataleptic activity

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Abstract

Structure-activity relationship of 8-styrylxanthines for in vivo adenosine A2A antagonism were explored. Diethyl substitution both at the 1- and 3-position was found to dramatically potentiate the anti-cataleptic activity.

Structure-activity relationships of 8-styrylxanthines for in vivo adenosine A2A antagonism were explored. Diethyl substitution at the 1- and 3-position was found to dramatically potentiate the anti-cataleptic activity.

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