Adenosine A2A antagonists with potent anti-cataleptic activity
Structure-activity relationships of 8-styrylxanthines for in vivo adenosine A2A antagonism were explored. Diethyl substitution at the 1- and 3-position was found to dramatically potentiate the anti-cataleptic activity.
References (14)
- et al.
Eur. J. Pharmacol.
(1989) - et al.
Neurosciene
(1991) Trends Pharmacol. Sci.
(1980)- et al.
Eur. J. Pharmacol.
(1994) - et al.
Eur. J. Pharmacol.
(1994) - et al.
Pharmacol. Rev.
(1994) - et al.
Naunyn Schmiedebergs Arch. Pharmacol.
(1990)
There are more references available in the full text version of this article.
Cited by (101)
Discovery of 1,3-diethyl-7-methyl-8-(phenoxymethyl)-xanthine derivatives as novel adenosine A<inf>1</inf>and A<inf>2A</inf>receptor antagonists
2016, Bioorganic and Medicinal Chemistry Letters1,3,7-Triethyl-substituted xanthines - Possess nanomolar affinity for the adenosine A<inf>1</inf> receptor
2015, Bioorganic and Medicinal ChemistrySynthetic approaches to the 2013 new drugs
2015, Bioorganic and Medicinal ChemistryCitation Excerpt :Nitrosation of 96 with NaNO2/AcOH/H2O, followed by Na2S2O4/NH3-mediated nitroso reduction provided 5,6-amino-1,3-diethyluracil (97).110,111 Even though other groups have recently reported modified scale routes to istradefylline,106 the route described herein will focus on the sequence outlined by Kyowa Hakko Kogyo research laboratories during their initial development of istradefylline.109,112–114 EDC-mediated amine coupling involving 97 and 3,4-dimethoxycinnamic acid (98) led to the corresponding amide intermediate.
8-Substituted 2-alkynyl-N<sup>9</sup>-propargyladenines as A<inf>2A</inf> adenosine receptor antagonists
2014, Bioorganic and Medicinal ChemistryMultifunctional enzyme inhibition for neuroprotection - A focus on MAO, NOS, and AChE inhibitors
2014, Drug Design and Discovery in Alzheimer's Disease
Copyright © 1997 Published by Elsevier Ltd.