Synthesis and biological activities of phenyl piperazine- based peptidomimetic growth hormone secretagogues
A new class of potent orally active phenyl piperazine-based GH secretagougues such as compound 17 (L-163,689, EC50 = 6.3 mM) have been discovered from attempts to mimic the arrangement of the phenyl substituent in the spiroindanyl piperidine and spiroindoline sulfonamide privileged structures of 4 and 1, respectively.
References (11)
- et al.
- et al.
Bioorg. Med. Chem. Lett.
(1996) - et al.
Bioorg. Med. Chem. Lett.
(1996) - et al.
Science
(1993) - et al.
There are more references available in the full text version of this article.
Cited by (0)
Copyright © 1998 Published by Elsevier Ltd.