Trends in Biochemical Sciences
Making sense of nonsense in yeast
References (31)
Cell
(1994)- et al.
Gene
(1988) - et al.
Cell
(1991) - et al.
J. Biol. Chem.
(1995) Microbiol. Rev.
(1995)- Weng, Y. et al. Modern Cell Biology.Post-transcriptional Gene Regulation: Today's RNA World (in...
RNA
(1995)- et al.
Proc. Natl. Acad. Sci. U.S.A.
(1979) - et al.
Genes Dev.
(1993) - et al.
Mol. Cell. Biol.
(1995)
Mol. Cell. Biol.
Nature
Genes Dev.
Mol. Cell. Biol.
EMBO J.
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A mathematical modelling framework for elucidating the role of feedback control in translation termination
2010, Journal of Theoretical BiologyThe Shuttling Protein Npl3 Promotes Translation Termination Accuracy in Saccharomyces cerevisiae
2009, Journal of Molecular BiologyCitation Excerpt :In this study, we report that two proteins (Npl3p and Upf1p) previously shown to be involved in different steps of gene expression have a common function in translation termination. The mRNA-binding protein Npl3p functions in mRNA processing, transcription termination, and RNA export,28,29,31,35 while the RNA helicase Upf1p is a central component of the NMD RNA surveillance pathway.51–53 We provide several lines of evidence indicating that Npl3p and Upf1p function in translation termination in yeast.
Abnormally spliced β-globin mRNAs: A single point mutation generates transcripts sensitive and insensitive to nonsense-mediated mRNA decay
2002, BloodCitation Excerpt :Moreover, our data indicate that neither abnormalities of splicing nor translation reinitiation at downstream AUG codons is a plausible explanation for the NMD resistance of this transcript (Figures 2-4). Contrary to results predicted by the generally used model,1-3,9,17,18 our data showed that aberrantly spliced transcripts are not always targeted by the NMD machinery. This finding suggests the existence of additional, unidentified determinants that function to modulate the NMD sensitivity of these transcripts.
Viral strategies of translation initiation: Ribosomal shunt and reinitiation
2002, Progress in Nucleic Acid Research and Molecular BiologyRegulation of c-myc mRNA decay in vitro by a phorbol ester-inducible, ribosome-associated component in differentiating megakaryoblasts
2000, Journal of Biological ChemistryCitation Excerpt :Alternatively, destabilization could involve deadenylation-independent decapping and 5′→3′ degradation of c-myc mRNA via an Xrn1-like activity (48). Such a mechanism is responsible for nonsense-mediated mRNA decay in the yeast Saccharomyces cerevisiae (reviewed in Refs. 49-51) and possibly in mammalian cells as well (52). In summary, c-myc mRNA is destabilized during differentiation of K562 cells to megakaryoblasts.
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M. J. Rulz-Echevarria, K. Czaplinski and S.W. Peltz are at the Department of Molecular Genetics and Microbiology, University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School, 675 Hoes Lane, Piscataway, NJ 08854, USA.