Immunity
Volume 20, Issue 5, May 2004, Pages 517-527
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Review
Pathogenic Roles of B Cells in Human Autoimmunity: Insights from the Clinic

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Abstract

The pathogenic roles of B cells in human autoimmune diseases involve a multitude of mechanistic pathways and include the well-established contributions of autoantibodies and immune complexes that induce local inflammatory reactions and tissue destruction. Recent results using several novel B cell-directed therapies have provided new insights into additional roles of B cells in human autoimmunity. In this review, we will highlight some of these studies and discuss how clinical insights parallel murine models of normal immunity and autoimmunity.

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