The International Journal of Biochemistry & Cell Biology
ReviewThe CD38/cyclic ADP-ribose system: A topological paradox
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Roles of cADPR and NAADP in pancreatic beta cell signaling
2022, Cell CalciumCitation Excerpt :Thus, this raises a topological problem regarding how the ectoenzyme produces cADPR by using the intracellular substrate NAD, and how cADPR reaches and acts on its intracellular target channel. De Flora's group has proposed a hypothetical model to solve the topological problem [36]: CD38 is internalized through endocytic vesicle formation, and the influx of NAD into endocytic vesicles [37] and the exit of cADPR occurs via nucleotide channels [38]. Ectoenzyme activity seems to be indispensable for cADPR production as well as insulin secretion in pancreatic islets, suggesting that CD38 internalization is prerequisite for cADPR production [39].
Targeting CD38-dependent NAD<sup>+</sup> metabolism to mitigate multiple organ fibrosis
2021, iScienceCitation Excerpt :The multifunctional NADase enzyme CD38 is a type II plasma membrane protein expressed on both immune and non-immune cells. CD38 shows ectoenzyme activity with the catalytic site facing the outside of the cell (De Flora et al., 1997; Boslett et al., 2018a; Chatterjee et al., 2018). CD38 is also present on intracellular organelles, including the nucleus and mitochondria (Sun et al., 2002; Aksoy et al., 2006a; Zhao et al., 2012; Peclat et al., 2020).
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