Short communicationThe synergistic effects of betulin with acyclovir against herpes simplex viruses
References (21)
- et al.
Lupane triterpenes and derivatives with antiviral activity
Bioorg. Med. Chem. Lett.
(2003) - et al.
Quantitative analysis of dose–effect relationships: the combined effects of multiple drugs or enzyme inhibitors
Adv. Enzyme Regul.
(1984) Antiviral drugs: current state of the art
J. Clin. Virol.
(2001)- et al.
Herpes simplex virus latency and nucleoside analogues
Antiviral Res.
(1999) - et al.
Evidence of dual sites of action of dendrimers: SPL-2999 inhibits both virus entry and late stages of herpes simplex virus replication
Antiviral Res.
(2002) - et al.
3,28-Di-O-(dimethylsuccinyl)-betulin isomers as anti-HIV agents
Bioorg. Med. Chem. Lett.
(2001) - et al.
Molecular mechanisms of antiviral resistance
Antiviral Res.
(1995) - et al.
Antiviral activity of betulin, betulinic and betulonic acids against some enveloped and non-enveloped viruses
Fitoterapia
(2003) - et al.
Anti-AIDS agents. 32. Synthesis and anti-HIV activity of betulin derivatives
Bioorg. Med. Chem. Lett.
(1998) - et al.
Inhibitory effects of triterpenoids and sterols on human immunodeficiency virus-1 reverse transcriptase
Lipids
(2001)
Cited by (57)
Plant species richness regulated by geographical variation down-regulates triterpenoid compounds production and antioxidant activities in white birch bark
2023, Flora: Morphology, Distribution, Functional Ecology of PlantsNovel betulin dicarboxylic acid ester derivatives as potent antiviral agents: Design, synthesis, biological evaluation, structure-activity relationship and in-silico study
2021, European Journal of Medicinal ChemistryCitation Excerpt :For example, the first effective antiviral drug, acyclovir, which is used in the treatment of HHV infections, is a DNA polymerase inhibitor [24]. Research shows that betulin combined with acyclovir exhibits synergistic effects against HHV-1 and HHV-2 viruses [25]. Considering the results of research on the antiviral activity of betulin 1, it is appropriate to obtain betulin 1 derivatives containing the common structural elements of widely available drugs.
Betulin and its derivatives as novel compounds with different pharmacological effects
2020, Biotechnology AdvancesIonic derivatives of betulinic acid exhibit antiviral activity against herpes simplex virus type-2 (HSV-2), but not HIV-1 reverse transcriptase
2015, Bioorganic and Medicinal Chemistry LettersPentacyclic triterpenes in birch bark extract inhibit early step of herpes simplex virus type 1 replication
2014, PhytomedicineCitation Excerpt :Experiments to assess the cytotoxicity of TE and pentacyclic triterpenes indicated a low toxic behaviour in cell cultures (RC 37) according to Halle and Göres (1987). This is in accordance with Gong et al. (2004), who demonstrated also a low cytotoxicity for betulin in cell culture on Vero cells. We have analyzed the in vitro inhibitory effect of TE and related pentacyclic triterpenes on HSV-1 strains using plaque reduction assays.
Antiviral potency of lupane and oleanane alkynyl-derivatives against human cytomegalovirus and papillomavirus
2024, Journal of Antibiotics