Effect of capsaicin-evoked jaw-muscle pain on intramuscular blood-flow
Section snippets
Background
The most common complaint of patients with jaw-muscle disorders is a spontaneous deep ache often associated with tenderness to palpation or pain on movement.1, 2 Operationalized criteria for so-called myofascial temporomandibular pain (TMD) has been developed as described in the Research Diagnostic Criteria for TMD.3 Simons and Mense4 hypothesised that the compromised blood flow (BF) plays an important role in the development of muscle pain and tenderness subsequently leading to an energy
Subjects
Eight healthy men (mean age: 25.4 ± 3.7 years, range 22–31 years) participated in this study. All were University students and were in good health. The absence of painful muscle disorders and temporomandibular joint problems were checked in accordance with the Research Diagnostic Criteria (RDC) for TMD.3 Furthermore, none of the subjects took medication which could influence pain responses or vascular responses. Informed consent was obtained from each subject prior to inclusion, and the
Effect of intramuscular injections with the jaw at rest
The capsaicin injection evoked moderate pain which was rated as 37.5 ± 13.9 on the VAS 5 min after the injection and lasted for a total of 14.9 ± 1.4 min. In contrast, the injection of isotonic saline was associated with no or very low levels of pain (5.0 ± 10.0) and only lasted for 4.6 ± 1.7 min.
Immediately after the capsaicin and saline injections, BF in the right masseter muscle was significantly increased (Fig. 2A–D, Dunnett’s tests: P < 0.050). However, in both sessions the BF rapidly (about 30 s)
Discussion
This study demonstrated immediately after the capsaicin injection, cutaneous BF increases over the masseter muscle on the injection side, and cutaneous BF decreases in the middle finger with no BF changes in the contralateral cutaneous BF over the masseter muscle. The results also showed intramuscular BF increases evoked by submaximal levels of masseter muscle contraction but failed to show effects of contraction levels on intramuscular BF in a painful muscle. This study provides some
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