Leading OpinionSmart biomaterials design for tissue engineering and regenerative medicine☆
Section snippets
Smart biomaterials
In its simplest form a tissue engineering (TE) scaffold provides mechanical support, shape, and cell-scale architecture for neo-tissue construction in vitro or in vivo as seeded cells expand and organize. Most degradable biomaterials used to date comprise a class of synthetic polyesters such as poly(l-lactic acid) (PLLA) and poly(l-glycolic acid) (PLGA), and/or natural biological polymers such as alginate, chitosan, collagen, and fibrin [1]. A multitude of fabrication techniques have been
Summary
It is evident from the foregoing examples that the diversity in biomaterials is immense. Many clever approaches to mimicking the structure, and more importantly, the function of the ECM have been devised. It is imperative that these important technologies continue to be investigated for their ability to interact in biological systems. An essential toolset has previously been described that will enable comprehensive evaluation of novel biomaterials in their host environment. Successful
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Note: Leading Opinions: This paper provides evidence-based scientific opinions on topical and important issues in biomaterials science. They have some features of an invited editorial but are based on scientific facts, and some features of a review paper, without attempting to be comprehensive. These papers have been reviewed for factual, scientific content.