Archival ReportHigh Impulsivity Predicts Relapse to Cocaine-Seeking After Punishment-Induced Abstinence
Section snippets
Animals
Outbred male Lister Hooded rats (Charles River, Margate, United Kingdom) weighing 250–275 g at the beginning of the experiments were used. Rats were housed in groups of four during testing on the 5-CSRTT and were individually housed after intravenous catheterization. Rats were fed at the end of each day's testing and housed under temperature- and humidity-controlled conditions and a reversed 12-hour light/dark cycle (lights off at 7:00 am). All experimental procedures conformed to the UK (1986)
Experiment 1: Relapse to Cocaine-Seeking in HI and LI Rats
The HI (n = 8) and LI (n = 14) animals (Table 1 in Supplement 1) rapidly acquired cocaine self-administration under the seeking-taking chained schedule of reinforcement and to nose-poke into the magazine to obtain sucrose (Figure 1C). At the end of the training phase all animals received similar overall numbers of cocaine infusions and sucrose reinforcement (data not shown). During punishment, 6 HI and 10 LI rats progressively decreased cocaine-seeking [F(7,98) = 51.7; p < .01] (Figure 1A) and
Discussion
The results of the present study show that HI rats have an increased propensity to relapse after abstinence induced by the suppression of drug-seeking responses by intermittent punishment. Whereas LI rats only relapsed after a first but not a second phase of the suppression of drug-seeking by punishment, HI rats readily reinstated their drug-seeking after the second punishment phase, and this tendency was greatly increased after prolonged access to cocaine.
Relapse to compulsive drug use is a
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2021, Behavioural Brain ResearchCitation Excerpt :Of the model traits for cocaine addiction risk we evaluated in SHR/NCrl and SHR/NHsd, compulsive-like behavior and initial sensitivity to acute 20 mg/kg cocaine were the best predictors of cocaine seeking and cocaine taking behaviors, respectively. It was somewhat surprising that impulsive-like behavior was not a significant predictor of any aspect of cocaine self-administration behavior in this study, given its prominent association with cocaine self-administration in outbred Lister Hooded rats [18,66,85,86] and outbred Wistar rats [87,88]. Although both inhibitory control traits were heritable and were correlated in SHR/NCrl and SHR/NHsd, the compulsive-like behavioral phenotype might be relatively more important for predicting cocaine self-administration in an F2 population of rats that segregate SHR/NCrl and SHR/NHsd alleles.
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