The design and synthesis of sulfonamides as caspase-1 inhibitors
A series of sulfonamides has been prepared as inhibitors of interleukin-1β converting enzyme (ICE), also known as caspase 1. These compounds were designed to improve potency by rigidifying the enzyme bound molecule through an intramolecular hydrogen bond. An X-ray crystal structure of a representative member of this series bound to the active site of ICE, confirms the presence of the hydrogen bonding interaction.
References (24)
Biochem. Pharm.
(2002)et al.Eur. Cytokine Network
(2001)et al.Immunol. Today
(1991)Ann. N.Y. Acad. Sci.
(1998)- et al.
Int. J. Pept. Protein Res.
(1994)et al.Nature (London)
(1992)et al.Bioorg. Med. Chem. Lett.
(1993)Bioorg. Med. Chem. Lett.
(1992) - et al.
J. Immunol.
(1995) - et al.
Bioorg. Med. Chem. Lett.
(1993) - et al.
Bioorg. Med. Chem. Lett.
(1998) - (a) Abdel-Mequid, S. S.; Carr, T. J.; Desjarlais, R. L.; Gallagher, T. F.; Halbert, S. M.; Janson, C. A.; Marquis, R....(b) Carr, T. J.; Desjarlais, R. L.; Gallagher, T. F.; Halbert, S. M.; Oh, H.-J.; Thompson, S. K.; Veber, D. F.;... et al.
J. Am. Chem. Soc.
(1998)et al.J. Am. Chem. Soc.
(1997) - Lubisch, W.; Moeller, A.; Treiber, H.-J.; Knopp, M. In Ger. Offen., BASF A.-G., Germany: DE 19817461,...
Tetrahedron Lett.
(1994)- The assay conditions and chemistry are reported in: Albrecht, H. P.; Allen, H. J.; Brady, K. D.; Harter, W. G.;...
Curr. Pharm. Des.
(2003)
et al.Infect. Immun.
(1991)
et al.Cytokine
(1991)
(d) Carmichael, D. F.; Smith, C. G.; Thompson, R. C. Can. Pat. Appl., Synergen, Inc., CA, USA, CA 2039458,...Exp. Cell Res.
(1997)
et al.Neurobiol. Aging
(2001)
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