Cell
Volume 141, Issue 5, 28 May 2010, Pages 834-845
ArticleA Bivalent Tarantula Toxin Activates the Capsaicin Receptor, TRPV1, by Targeting the Outer Pore Domain
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Graphical Abstract
Highlights
► DkTx is a spider toxin that irreversibly activates the capsaicin receptor, TRPV1 ► DkTx's tandem-repeat sequence underlies its bivalent, high-avidity TRPV1 interaction ► DkTx and related toxins bind to residues within the outer pore domain of TRPV1 ► Conformational changes in the outer pore are critical for TRP channel activation
MOLNEURO
SIGNALING
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These authors contributed equally to this work
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Present address: Max-Delbrück-Centrum für Molekulare Medizin, Berlin-Buch, Robert-Rössle-Strasse 10, 13125 Berlin, Germany
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