Cell
Volume 143, Issue 5, 24 November 2010, Pages 682-685
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Ubiquitin: Same Molecule, Different Degradation Pathways

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Ubiquitin is a common demoninator in the targeting of substrates to all three major protein degradation pathways in mammalian cells: the proteasome, the lysosome, and the autophagosome. The factors that direct a substrate toward a particular route of degradation likely include ubiquitin chain length and linkage type, which may favor interaction with particular receptors or confer differential susceptibility to deubiquitinase activities associated with each pathway.

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