Cell
ArticleUnidirectional Cross-Activation of GRPR by MOR1D Uncouples Itch and Analgesia Induced by Opioids
Graphical Abstract
Highlights
► Unique isoforms of the μ-opioid receptor (MOR) separate itch from analgesia ► Heterodimers of MOR1D and gastrin-releasing peptide receptor (GRPR) form ► Molecular basis for opioid-induced itch relies on MOR1D activation of GRPR ► PLCβ3 and IP3R3 signal downstream of MOR1D-GRPR to trigger itch response
Cited by (0)
- 4
Present address: Department of Neurobiology and Anatomy, University of Texas Medical School, Houston, TX 77030, USA
- 5
Present address: Haverford College, Haverford, PA 19041, USA
- 6
Present address: Department of Anesthesiology, National Taiwan University Hospital, Yun-Lin Branch, Yunlin County 640, Taiwan (R.O.C.)
- 7
Present address: Department of Anesthesiology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, P.R. China