Cell Metabolism
Volume 11, Issue 6, 9 June 2010, Pages 554-565
ResourceUse of Cells Expressing γ Subunit Variants to Identify Diverse Mechanisms of AMPK Activation
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Graphical Abstract
Highlights
► AMPK is activated by a wide variety of different stresses, drugs, and xenobiotics ► We have developed a sensitive method to test which activators are AMP mediated ► Most, e.g., metformin and resveratrol, inhibit mitochondrial function and elevate AMP ► However, we can now distinguish six different mechanisms for AMPK activation
HUMDISEASE
SIGNALING
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