Rhinitis, sinusitis, and ocular diseasesExpression of the cysteinyl leukotriene receptors cysLT1 and cysLT2 in aspirin-sensitive and aspirin-tolerant chronic rhinosinusitis
Section snippets
Patients
Nasal biopsy specimens were obtained from 32 patients with chronic rhinosinusitis, as defined by the presence of nasal polyps, and 9 normal control subjects with a lifelong absence of perennial or seasonal nasal symptoms. Of the patients with rhinosinusitis, 21 were aspirin-sensitive, and 11 were aspirin-tolerant. Eighteen of the 21 aspirin-sensitive patients, 8 of the 11 tolerant-patients, and 7 of the 9 normal controls were atopic as defined by a positive skin prick test to 1 or more of a
Expression of cysLT1 and cysLT2 on nasal mucosal leukocytes
The absolute numbers of CD45+ leukocytes as well as percentages of these cells expressing cysLT1 and cysLT2 in all of the patients with chronic rhinosinusitis assessed as a single group and normal controls are shown in Fig 1. Significantly elevated percentages of nasal mucosal leukocytes expressed cysLT1 but not cysLT2 in the patients with rhinosinusitis compared with the normal controls (cysLT1 controls: median, 4.2; range, 0.9-15.6; rhinitis: median, 18.0; range, 2.2-51.8; P = .002; cysLT2
Discussion
We have shown in this study that elevated expression of cysLT1 on nasal mucosal inflammatory leukocytes is a phenomenon confined to aspirin-sensitive patients with rhinosinusitis. In contrast, these same cells showed no evidence of upregulation of cysLT2 in patients with rhinosinusitis, whether aspirin-sensitive or aspirin-tolerant, compared with controls. These data considerably extend our previous study.15
The data in this and our previous study15 confirm that subsets of leukocytes of all
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