When administered into the nucleus accumbens core or shell, the NMDA receptor antagonist AP-5 reinstates cocaine-seeking behavior in the rat
Section snippets
Acknowledgements
This research was supported by grants from the National Institutes of Health (NIH) to R.C.P. (R01 DA15214 and K02 DA18678). K.R.F. was also supported by a National Research Service Award (NRSA) from the NIH (F30 DA19304), as well as an NIH training grant (T32 GM008541-7). H.D.S. was also supported by an NRSA from the NIH (DA16824). The authors would like to thank Audrey Pierce for administrative assistance and Judy Yee for technical support.
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2019, Asian Journal of PsychiatryCitation Excerpt :The skin on the head was incised and the underlying periosteum was removed. Two stainless steel, 23-gauge guide cannulae were bilaterally implanted 2 mm above the intended site of injection (Famous et al., 2007). Stereotaxic coordinates for the shell part of the NAc were: 1 mm anterior to bregma, ± 1 mm lateral to the sagittal suture, and 5 mm from skull (Paxinos and Watson, 2007).
Modulatory effects of Ampicillin/Sulbactam on glial glutamate transporters and metabotropic glutamate receptor 1 as well as reinstatement to cocaine-seeking behavior
2017, Behavioural Brain ResearchCitation Excerpt :The intra-injections of drugs of abuse, including cocaine, directly into the NAc shell, have been found to play a role in the development of conditioned reinforcement [33,34] and motor response to dependence drugs [35,36]. However, the NAc core has been found to mediate cue-induced reinstatement of cocaine-seeking behavior [33,37–39]. Furthermore, the PFC has been suggested to be implicated in drug-seeking behavior [40].
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Present address: Department of Psychiatry, Yale University School of Medicine, New Haven, CT, United States.