Modanifil activates the histaminergic system through the orexinergic neurons
Section snippets
Acknowledgement
We are very grateful to Prof. Takeshi Sakurai (Department of Molecular Neuroscience and Integrative Physiology, Graduate School of Medical Science, Kanazawa University) for providing orexin neuron-deficient mice.
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2018, Progress in Neuro-Psychopharmacology and Biological PsychiatryCitation Excerpt :Beyond dopaminergic effects, both modafinil and METH interact with norepinephrine (NE) and histamine systems as part of their respective pharmacokinetics (Munzar et al., 2004; Ishizuka et al., 2010; Ferrucci et al., 2013; Wisor, 2013). Additionally, modafinil and METH have been shown to activate orexinergic neurons, which induces wakefulness by stimulation DA, NE and histamine neurotransmission (Estabrooke et al., 2001; Ishizuka et al., 2010; Mahler et al., 2012). Glutamatergic neurotransmission in the corticostriatal pathway is essential for motivated behaviors and it is well known that psychostimulant intake may alter synaptic plasticity (Kauer and Malenka, 2007; Parsegian and See, 2014; González et al., 2016).
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Present address: Division of Neurology/Molecular Brain Science, Kobe University School of Medicine, 7-5-1 Kusunoki-cho, Chuo-ku, Kobe, Hyogo 650-0017, Japan.